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Abstract
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Discussion
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gincosan

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The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers.

PMID:11026748
https://www.ncbi.nlm.nih.gov/pubmed/?term=11026748


Abstract
Rationale:¥¤¥Á¥ç¥¦ÍÕ¥¨¥­¥¹¡Ê¥®¥ó¥³¡Ë¤òĹ´ü¤ËÆâÉþ¤¹¤ë¤³¤È¤Ë¤è¤ê¡¢Ç§Ãε¡Ç½¤¬²þÁ±¤¹¤ë¤³¤È¤¬¤ï¤«¤Ã¤Æ¤­¤Æ¤¤¤Þ¤¹¡£

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ºÇ¶á¤Î¸¦µæ¤Ë¤è¤ê¡¢C£ÄR(Cognitive Drug Research)¤Ë¤è¤ê¬Äꤵ¤ì¤¿4¤Ä¤ÎǧÃιàÌÜ(Ãí°ÕÎϤήÅÙ¡¢Ãí°ÕÎϤÎÀµ³Î¤µ¡¢µ­²±¤Î®ÅÙ¡¢µ­²±¤ÎÀµ³Î¤µ)¤¬Ç§Ãε¡Ç½¤ÎÊѲ½¤ò¬Äꤹ¤ë¤Î¤ËÍ­ÍѤǤ¢¤ë¤³¤È¤¬¤ï¤«¤Ã¤Æ¤­¤Þ¤·¤¿¡£


Objective:º£²ó¤Î¸¦µæ¤Ç¤Ï¥®¥ó¥³¤òCDR4¹àÌܤËÌÀ³Î¤Ê¸ú²Ì¤ò¤â¤¿¤é¤¹¤«¤É¤¦¤«¤òɾ²Á¤·¤Þ¤·¤¿¡£


Method:¤³¤Î¸¦µæ¤ÏÆó½ÅÌÕÌܥץ饻¥Ü¥³¥ó¥È¥í¡¼¥ë¸òºµ»î¸³¤Î·Á¤Ç¹Ô¤¤¤Þ¤·¤¿¡£

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Results:¥×¥é¥»¥Ü·²¤ÈÈæ³Ó¤·¤Æ¥®¥ó¥³¤òÆâÉþ¤¹¤ë¤È¿¤¯¤ÎÍ­°Õ¤ÊÊѲ½¤¬Ç§¤á¤é¤ì¤Þ¤·¤¿¡£

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240mg,360mgÆâÉþ·²¤É¤Á¤é¤â¤ÇÍ­°Õ¤Ê²þÁ±¤¬Ç§¤á¤é¤ì¡¢ÆâÉþ2.5»þ´Ö¸å¤ÇºÇ¤â¤Ï¤Ã¤­¤ê¤·¤¿¸ú²Ì¤¬¤¢¤ê¡¢ÆâÉþ6»þ´Ö¸å¤Ç¤â¤½¤Î¸ú²Ì¤Ï»ý³¤·¤Æ¤¤¤Þ¤·¤¿¡£


Conclusion:º£²ó¤Î¸¦µæ¤Ç·ò¹¯¤Ê¼ã¤¤È︳¼Ô¤òÂоݤȤ·¤¿¸¦µæ¤Ç¥®¥ó¥³ÆâÉþ¤Ë¤è¤êÃí°ÕÎϤλý³Ū¤Ê²þÁ±¤¬Ç§¤á¤é¤ì¤Þ¤·¤¿¡£

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PMID: 30729756
https://www.ncbi.nlm.nih.gov/pubmed/?term=30729756


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PMID:11394191
https://www.ncbi.nlm.nih.gov/pubmed/?term=11394191

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PMID:2952762
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952762/



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Soybean-Drived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

PMID: 21103034

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https://www.ncbi.nlm.nih.gov/pubmed/?term=21103034


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Rerationship between Concentrations of Lutein and StARD3 among Pediatric and Geriatric Himan Brain tissue

PMID: 27205891

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https://www.ncbi.nlm.nih.gov/pubmed/?term=27205891

Abstract
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Introduction
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[1] E.williamson, ¡ÈCentella asiatica(L.) Urb,¡É in major Herbs of Ayurveda, E. Williamson, Ed., pp. 102-110, Elsevier Science, London, UK, 2002.
[2] J.Pan, G,Kai, C.Yuan, B.Zhou, R.jun, and Y.Yuan, ¡ÈSeparation and determination of madecassic acid in extracts of Centella asiatica using high performance liquid chromatography with ¦Â-cyclodextrin as mobile phase additive,¡É Chinese Journal of Chromatography, vol. 25, no. 3, pp. 316-318, 2007.
[3] N. P. Safu, S. K. Roy, and S. B. Mahat, ¡ÈSpectroscopic determination of structures of triterpenoid trisaccharides from Centella asiatica,¡É Phytochemistry, vol. 28, no. 10, pp. 2852-2854, 1989
[4] M. Kuroda, Y. Mimaki, H. Harada, H. Sakagami, and Y. sashida, ¡ÈFive new triterpene glycosides from Centella asiatica,¡É Natural Medicines, vol. 55, no. 3, pp. 134-138, 2001.
[5] B. S. Siddeiqui, H. Aslam, S. T. Ali, S. Khan, and S, Begum, ¡ÈChemical constituents of Centella asiatica,¡É Journal of Asian Natural Products Research, vol. 9, no. 4, pp. 407-414, 2007.
[6] Y. N. Shukla, R. Srivastava, A. K. Tripathi, and V. Prajapati, ¡ÈCharacterization of an ursane triterpenoid from Centella asiatica with growth inhibitory activity against Spilarctia obliqua,¡É Pharmaceutical Boilogy, vol.38, no.4 pp. 262-267, 2000.
[7] H. Matsuda, T. Morikawa, H. Ueda, and M. Yoshikawa, ¡ÈMedicinal foodstuffs. XXVI, Inhibitors of aldose reductase and new triterpene and its oligoglycoside, centellasapogenol A and centellasaponin A, from Centella asiatica (Gotu Kola),¡É Heterocycles, vol, 55, no. 8, pp. 1499-1504, 2001.
[8] H. matsuda, T. Morikawa, H. Ueda, and M. Yoshikawa, ¡ÈMedicinal foodstuffs. XXII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka,¡É Chemical and Pharmaceutical Bulletin, vol. 49, no. 10, pp. 1369-1371, 2001.
[9] M. Yoshida, M. Fuchigami, T. nagao et al., ¡ÈAntiproliferative constituents from umbelliferae plants VII. Active triterpenes and rosmarinic and from Centella asiatica,¡É Biological and Pharmaceutical Bulletin, vol. 28, no. l, pp. 173-175, 2005.
[10] C. S. Rumalla, Z. D. Weerasooriaya, T. J. Smillie , and I. A. Khan, ¡ÈTwo new triterpene glycosides from Centella asiatica,¡É Planta Medica, vol. 76, no. 10, pp. 1018-1021, 2010.
[11] R. Tenni, G. Zanaboni, M. P. De Agostini, A. Rossi, C. Bendotti, and G. Cetta, ¡ÈEffect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in fuman skin fibroblast cultures,¡É Italian Journal of Biochemistry, vol. 37, no. 2, pp. 69-77, 1988.
[12] L. Suguna, P. Ssivakumar, and G. Chandrakasan, ¡ÈEffects of Centella asiatica extract on dermal wound healing in rats,¡É Indian Journal of Experimental Biology, vol. 34, no. 12, pp. 1208-1211, 1966.
[13] B. S. Shetty, S. L. Udupa, and A. L. udupa, ¡ÈBiochemical analysis of granulation tissue in steroid and Centella asiatica (Linn) treated rats,¡É Pharmacologyonline, vol. 2, pp. 624-632, 2008.
[14] M. N. Somchit, M. R. Sulaiman, A. Zuraini et al., ¡ÈAntinociceptive and anti-inflammatory effects of Centella asiatica,¡É Indian Journal of Pharmaology, vol.36, no. 6, pp. 377-380, 2004.
[15] M. George, L. Joseph, and Ramaswamy, ¡ÈAnti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts,¡É African Journal of Traditional, Complementary and Alternative Medicines, vol. 6, no. 4, pp. 554-559, 2009.
[16] J. H. Sampson, A. Raman, G. Karlsen, H. Navsaria, and I. Leigh, ¡ÈIn vitro Keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins,¡É Phytomedicine, vol. 8, no.3, pp. 230-235, 2001.
[17] C. L. Cheng and M. W. W. L. Koo, ¡ÈEffects of Centella asiatica on ethanol induced gastric mucosal lesions in rats,¡É Life Sciences, vol. 67, no. 21, pp 2647-2653, 2000.
[18] C. L. Cheng, J. S. Guo, J. Luk, and M. W. L. Koo, ¡ÈThe healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats,¡É Life Sciences, vol. 74, no. 18, pp. 2237-2249, 2004.
[19] S. S. Pingale, ¡ÈEvaluation of effect of Centella asiatica on CCL induced rat liver damage,¡É Pharmacologyonline, vol. 3, pp. 537-543, 2008.
[20] S. Sudha, S. Kumaresan, A. Amit, J. David, and B. V. Venkataraman, ¡ÈAnti-convulsant activity of different extracts of Centella asiatica and Bacopa monnieri in animals,¡É Journal of Natural Remedies, vol. 2, no. 1, pp . 33-41, 2002.
[21] P. Wijeweera, J. T. Arnason, D. Koszycki, and Z. Merali, ¡ÈEvaluation of anxiolytic properties of Gotukola (Centella asiatica) extracts and asiaticoside in rat behavioral models,¡É Phytomedicine, vol. 13, no. 9-10, pp. 668-676. 2006.
[22] X. S. Wang, Q. Dong, J. P. Zuo, and J. N. fang, ¡ÈStructure and potential immunological activity of a pectin from Centella asiatica (L.) Urban,¡É Carbohydrate Research, vol. 338, no. 22 pp. 2393-2402, 2003.
[23] A. Gnanapragasam, K. Kumar Ebenezar, V. Sathish, P. Govindaraju, and T. Devaki, ¡ÈProtective effect of Centella asiatica on antioxidant tissue defense system against Adriamycin infused cardiomyopathy in rats,¡É Life Sciences, vol. 76, no. 5, pp. 585-597, 2004.
[24] M. Raghavendra, R. Maiti, S. Kumar, A. Trigunayat, S. Mitra, and S Acharya, ¡ÈRole of Centella asiatica on cerebral postischemic reperfusion and long-term hypoperfuion in rats,¡É International Journal of Green Pharmacy, vol. 3, no. 2, pp. 88-96, 2009.
[25] M. L. Venu Gopal Rao and S. A. Mastan, ¡ÈAntidiabetic effects of methanolic extract of Centella asiatica (Linn.) on induced hyperglycemic rats,¡É Biosciences Biotechnology Research Asa, vol. 4, no. 2, pp. 721-724, 2007.
[26] C. Yoosook, N, Bunyapraphatsara, Y. Boonyakiat, and C, Kantasuk, ¡ÈAnti-herpes simples virus activities of crude water extracts of Thai medicinal plants,¡É Phytomedicine, vol. 6, no. 6, pp. 411-419, 2000.
[27] M. R. Zaidan, A. Noor Rain, A. R. Badrul, A. Adlin, A. Norazah, and I. Zakiah, ¡ÈIn vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method,¡É Tropical Biomedicine, vol. 22, no. 2, pp. 165-170, 2005.
[28] N. Senthilkumar, P.Varma, and G. Gurusubramanian, ¡ÈLarvicidal and adulticidal activities of some medicinal plants against the Malarial Vector, Anopheles stephensi (Liston),¡É Parasitology Research, vol. 104, no. 2, pp. 237-244, 2009.
[29] E. Naz and M. Ahmad, ¡ÈEvaluation of five indigenous medicinal plants of Sindh, Pakistan for their antifungal potential,¡É Pakistan Journal of Scientific and Industrial Research, vol. 52, no. 6, pp. 328-333, 20093
[30] A. A. Hamid, Z. shah, R. Muse, and S. Moharned, ¡ÈCharacterisation of antioxidative activities of various extracts of Centella asiatica (L) Urban,¡É Food Chemistry, vol. 77, no. 465-469, 2002.
[31] G. Jayashree, G. Kurup Muraleedhara, S. Sudarslal, and V. B. Jacob, ¡ÈAnti*oxidant activity of Centella asiatica on lymphoma-bearing mice,¡É Fitoterapia, vol. 74, no. 5, pp. 431-434, 2003.
[32] M. Bajpai, A. Pande, S. K. Tewari, and D. Prakash, ¡ÈPhenolic contents and antioxidant activity of some food and medicinal plants,¡É International Journal of Food Sciences and Nutrition, vol. 56, no. 4, pp. 287-291, 2005.
[33] P. K. Mukherjee, V. Kumar, and P. J. Houghton, ¡ÈScreening of Indian medicinal plants for acetylcholinesterase inhibitory activity,¡É Phytotherapy Research, vol. 21, no. 12, pp. 1142-1145, 2007.
[34] R. Award, D Levac, P. Cybulska, Z. Merali, V. L. Trudeau, and J. T. Arnason, ¡ÈEffects of traditionally used anxiolytic botanicals on enzymes of the ¦Ã-aminobutyric acid (GABA) system,¡É Canadian Journal of Physiology and Pharmacology, vol. 85, no. 9, pp. 933-942, 2007.
[35] A. Soumyanath, Y. P. Zhong, S. A. Gokd et al., ¡ÈCentella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro,¡É Journal of Pharmacy and Pharmacology, vol. 57, no. 9, pp. 1221-1229, 2005.
[36] M. K. Lee, S. R. Kim, S. H. Sung et al., ¡ÈAsiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxcity.¡É Research Communications in Molecular Pathology and Pharmacology, vol. 108, no. 1-2, pp. 75-86, 2000.
[37] M. H. Veerendra Kumar and Y. K. Gupta, ¡ÈEffect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer¡Çs disease in rats,¡É Clinical and Experimental pharmacology and physiology, vol. 30, no. 5-6, pp. 336-342, 2003.
[38] Y. K. Gupta, M. H. V. Kumar, and A. K. Srivastava, ¡È
[39] S. B. Rao, M. Chetana, and P. Uma Devi, ¡ÈCentella asitaca treatment during postnatal period period enhances learning and memory in mice,¡É Physiology and behavior, vol. 86, no. 4, pp. 449-457, 2005.
[40] M. R. Gadahad, M. Rao, and G, Rao, ¡ÈEnhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats,¡É journal of the Chinese Medical Association, vol. 71, no. 1, pp. 6-13, 2008.
[41] M. Dhanasekaran, L. A. Holcomb, A. R. Hitt et al., ¡ÈCentella asiatica extract selectively decreases amyloid ¦Â levels in hippocampus of alzheimer¡Çs disease animal model,¡É Phytotherapy Research, vol. 23, no. 1, pp. 14-19, 2009.
[42] G. K. Shinomol and K. Muralidhara, ¡ÈEffect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria,¡É Phytomedicine, vol. 15, no. 11, pp. 971-084, 2008.
[43] S. Sudha, S. Kumaresan, A. Amit, J. David, and B. V. Venlataraman, ¡ÈAanti-convulsant activity of different extracts of Centella asiatica and Bacopa monnieri in animals,¡É Journal of Natural Remedies, vol. 2, no. 1, pp. 33-41, 2002.
[44] M. Bajpai, A Pande, S. K. Tewari, and D. Prakash, ¡Èphenolic contents and antioxidant activity of some food and medicinal plants,¡É International Journal of food Sciences and Nutrition, vol. 56, no. 4, pp. 287-291, 2005.
[45] M. Hussin, A. Abdul-Hamid, S. Mohamad, N. Saari, M. Ismail, and M. H. Bejo, ¡ÈProtective effect of Centella asiatica aqueous extract and powder on oxidative stress in rats,¡É Food Chemistry, vol. 100, no. 10, pp. 980-988, 2007.
[46] M. V. R. Appa Rao, K. Srinivasan, and T. Koteswara Rao, ¡ÈThe effect of Centella asiatica on the general mental ability of mentally retarded children,¡É Indian Journal of Psychiatry, vol. 19, no. 4, pp. 54-59.1977.
[47] J. Wattanathorn, L. Mator, S. Muchimapura et al., ¡ÈPositive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica,¡É Journal of Ethnopharmacology, vol. 116, no. 2, pp. 325-332, 2008.
[48] R. D. O. Dev, S. Mohamed, Z. Hambali, and B, A. Samah, ¡ÈComparison on cognitive effects of Centella asiatica in healthy middle age female and male volunteers,¡É European Journal of Scientific Research, vol. 31, no. 4, pp. 553\565, 2009.
[49] S. Tiwari, S. Singh, K. Patwardhan, S. Gehlot, and I. S. Gambhir, ¡ÈEffect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems,¡É Digest journal of Nanomaterials and Biostructures, vol. 3, pp. 215-220, 2008.
[50] I. Bilbao, A. Aguirre, R. Zabala, R. Gonzalez, J. Raton, and J. L. D. Perez, ¡ÈAllergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract,¡É Contact Dermatitis, vol. 33, no. 6, pp. 435-436, 1995.
[51] M. A. Gonzalo-Garijo, F. Revenga-Arranz, and P. Bobadilla-Gonzalez, ¡ÈAllergic contact dermatitis due to Centella asiatica : a new case,¡É Allergy and Immunopathology, vol. 24, pp. 132-134, 1996.
[52] J. Gomes, T. Pereira, C. Vilarinho, M. D. L. Duarte, and C. Brito, ¡ÈContact dermatitis due to Centella asiatica,¡É Contact Dermatitis, vol. 62, no. 1, pp. 54-55, 2010.
[53] C. A. Newall, L. A. Anderson, and J. D. Phillipson, Herbal Medicines, Pharmaceutical press, London, UK, 1996.
[54] T. Dutta and U. P. Bssu, ¡ÈCrude extract of Centella asiatica and products derived from its glycosides as oral antifertility agents,¡É Indian Journal of Experimental Biology, vol. 6, no. 3, pp. 181-182, 1968.
[Êä­­¡] Savai J, Varghese A. Chintamaneni M, ¡ÈIn vitro assessment of CYP1A2 and 2C9 inhibition potential of Withania somnifera and Centella asiatica in fuman liver microsomes,¡É Drug Metabol personal ther, 41-137:30 (2), Jun, 2015.
[Êä­­¢] Savai J, Varghese A, Pandita N, Chintamaneni M. ¡ÈInvestigation of CYP3A4 and CYP2D6 Interactions of Withania somnifera and Centella asiatica in Human Liver Microsomes,¡É Phytother Res, 90-785:29 (5) , May, 2015.

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