ǯĶǾˤƥStARD3δط

Rerationship between Concentrations of Lutein and StARD3 among Pediatric and Geriatric Himan Brain tissue

PMID: 27205891

Ѥɽϥˤ
https://www.ncbi.nlm.nih.gov/pubmed/?term=27205891

Abstract
ƥϥΥɤǤꡢʹ֤ǾŪ¸ߤƤޤ

¿θˤƥǧεǽδ֤ˤϴϢ뤳ȤƤϤޤƥǾȿؤμߤ䤽οпĹؤαƶǧεǽؤʬҳŪ٥ǤɾϤޤʤΤǤ

θŪ3Ĥǯء1-4ǯ55-86СĶ98-105СˤǾƥStARD3ȿˤƷȤ狼äƤޤˤȤδط餫ˤ뤳ȤǤ

Ǿƥǻ٤StARD3ǻ٤ˤĤƲϤԤޤ

η̡ǾǶشطǧ줿ΤǤ

ˤꡢƥϿпĹ˴ͿƤȤȤ狼ޤ

ǯǤϤδطͭդǤ夯ʤꡢ100ǤϴطͭդʤΤǤϤʤʤäƤޤ

100︡10ͤΤ7ͤǧξɤMCIξɾǧޤ

θǡˤStARD3θ䵡ǽ뤳Ȥޤ

StARD3ϿпĹΰ۾βθȹͤƤ륳쥹ƥ͢˴ϢƤꡢƥˤϤμФοݸǽǽޤ


Introduction
ΥɤϿʪ˰Ū˴ޤޤƤ뿧ǤǤ

40ΥΥɤʪ鸫ĤäƤޤ2ΥΥɡ륤ƥȥΤߤ̲᤹뤳ȤǤޤ

Ǥ3쥫ΥɷƱꤵƤꡢΤΤҤȤĤsteroidogenic acute regulatory domain 3(StARD3)ǤStARD3쥿ѥȤɬԲķʤΤǤꡢɥ꥽˦ﴱ¸ߤƤޤ

ƻ͢˴ؤäƤȹͤƤޤ

ǾǤΥ쥹ƥ͢ΰ۾ǯŤͤˤĤ٤Ƥ뤳ȤͤStARD3ǧεǽ˽פʴؤ꤬ǽꡢޤĥϥޡʤɤοΥ󥻥åȤˤʤäƤǽޤ

ΤᡢθǤǯ100ǾǤΥƥStARD3δϢɾ뤳ȤȤޤ


Materials and Methods(ȴ)
оݡ(1-4)ǯ(55-86)100(98-105)ǾȿĴԤޤ

Ǿȿˤ̤͡ޤޤƤꡢ(Hipp)¦Ƭ(TC)Ƭ(FC)Ƭ(OC)ޤ


Results
︡Ԥħɽʾά

Ǿƥǻ
Ǿƥǻ3ǤǾȿΥȥ󥹥ƥʿǻ٤ɽ2˵ܤƤޤ

٤ƤǾȿǥȥ-ƥ󤬸Фޤ

-ƥ175ͤΤߡǯǤ167ͤΤߡ100Ǥ154ͤΤߤǸФޤ

ƬդȳϤȤδ֡100Ƭդ¦ƬդȤδ֤ǤΥȥ-ƥǻ٤˺ϤޤǤ

ǯθƬեȥ-ƥǻ٤ϳϤΤ̤ͥ˹⤤Ȥ̤Ǥޤ(P<0.05)

ޤ100Ǿ٤ƤΥƥǻ٤ʿѤ椷ͭդ˹⤤Ȥ̤ˤʤޤ(P<0.05)


ǾStARD3٥
ǾȿStARD3ѥΥ٥ϥ֥åˡˤХɤǻ¬Ԥޤ(ɽ2)

Ƭդȳϴ֡ǯƬդ¦Ƭմ֤StARD3ХɤǻͭդʺϤޤǤ

ܤ٤ϥ-ƥ򸡽ФǤʤäǾȿӤƥ-ƥ򸡽ФǤǾȿǤͭդStARD3٥뤬⤫äΤǤ(P<0.05)Τ褦ʺǯ100ǤǧޤǤ


Ǿƥǻ٤StARD3٥δϢ
줾ηǾƥǻ٤StARD3٥δϢʬϤޤ

ǾΥȥ-ƥǻ٤StARD3Хɤǻͭդشطˤޤ(P<0.001)(1A)

Ǿγ̤ǸƬդǤͭդشطȤʤޤϤǤشطǧޤǤ

Ϥ̤ΥץʤäȤȹͤޤ

-ƥ⤹٤ƤǾȿStARD3Ȥͭդشطǧޤ(1BP<0.05)

ǯǤǾȥ-ƥǻ٤StARD3٥Ȥδ֤ˤϤ鷺شطǧޤ(P=0.053)(2A)

StARD3ȥ-ƥǻñȤStARD3ƥǻ٤δ֤ˤͭդشطǧޤ(2B,C)(ȤP<0.05)

ƬդӳñȤǤͭդʴϢǤޤǤϥץȹͤޤ

˥ĥϥޡ¤δԤƲϤԤäƤ⡢ƥǻ٤StARD3٥Ȥδ֤ˤṲ̄ͥĤޤ

100ǤStARD3ȥȥ-ƥ󡢥-ƥƥȤδ֤˴ϢǧޤǤ(3A-3C)


Discussionʰȴ
η̤ǥƥStARD3Ȥδ֤ͭդʴϢ뤳ȤͤȡǾȿؤΥƥŪѤϤη祿ѥˤΤȹͤޤ

شط˶ǯǤ夤Τˡ100ǤϴطʤʤäƤޤʰά

Ǿ˥ƥŪ˽Ѥ뤳Ȥʻζشطˤƥ󤬼ǯοпĹ˽פ̤Ƥǽޤ

ǯˤƥStARD3δϢθϡˤStARD3θ⤷ϵǽȿǤƤǽޤ

θǤ⡢ƥStARD3δϢɾݤ˥ĥϥޡ¤򴵤äƤ︳ԤƲϤԤȡƥǻ٤StARD3٥شطϤϤäȤΤˤʤޤά


θǥƥ󤬿ͤǾ˦Ū˼ޤ뤳Ȥ狼ޤ

StARD3ƥŪ礹뤳ȤͤȡǾ˥ƥŪ˽Ѥ뤳ȤĤ⤷ޤ

StARD3ϢѥǤꡢƥǸĤäƤ19ϤȤθȡƥϥ˥塼֤Υåס󥯥˱ƶͿ륷ʥץμפʹʪǤꡢĴǽͭʪǤǽޤʰʲά

ѽλ

ƥϡǾץȰ֤Ť뤳ȤǤǤ

ǤϡƥѤƤ륹ޡȡץϤΤǤ礦

ƥ򤽤ŪѤƤΤϡΥ饤 SKYLIGHT 餤⤷ޤ

饤ȤˤϡƥΤۤˤǾη򹯥ݡȤԤǤ륯륯ߥ󡢥顢ԥʡեݻʤɤBBB̲᤹ǤޤޤƤˤ۹礵Ƥޤ

ƥܤη򹯤˴Ϳ뤳ȤϤΤȻפޤ

ȿռԤˤȤäơʥޥۤѥĹָ虜ޤ󤫤ˡܤǾη򹯤򥵥ݡȤSKYLIGHTϡ륢ƥȤʤ뤳ȤǤ礦

CK005

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