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ư㤤ͤˤ롢ǽؤE-OJ-01ʪʥ른 ˤθ

Effect of E-OJ-01 on cardiac Conditioning in Young Exercising Adults:A Randomised Controlled trial.

PMID:27930383
https://www.ncbi.nlm.nih.gov/pubmed/?term=27930383


Abstract
طʤŪ¡η򹯤ϱưѥեޥ󥹤˱ƶͿޤΥǡߤȡ翴äϻϤä⤿餷ޤ

ߥʥꥢ른ʡTAˤϿɤη򹯤ͭ͡פʱƶ뤳ȤʬäƤޤ

θϷ򹯤ʼǯˤTAʪE-OJ-01ˤο¡ξ֤򼨤ޡؤθ̤򸦵椹뤳ȤǤ


ǥ󡧥ಽܻηǹԤǯαưԤäƤ˥ץȤȤE-OJ-01Ƥäǡ̤Ȱɾޤ

32ͤη򹯤(18-40)ǻưԤäƤҤȤоݤ56400mgE-OJ-01⤷ϥץ饻ܤƤ餤ޤ

LVEF(Ψ)orMPImyocardial performance indexʢǽ㲼ĥǽ㲼ΤɤǤMPIͤ礹ˡˤơBorg RPE(Ūư(ưμŪô٤ͤɽΡ

ͤ㤤ۤɳڡ⤤ۤɤĤưȤʤ))򸦵泫28ܡ56ܤɾޤ

ˡ56ܤCK-MBӥȥݥ˥TͤˤĤƤɾԤޤ


̡ץ饻ܷӤ56ܤλE-OJ-01ǤLVEFͭդʲǧ(P=0.0001)ޤMPIͭդ㲼ǧޤ(P=0.001)

BorgǤȤ館뱿ưϫ٤Ǥϥץ饻ܷӤE-OJ-01Ǥϸǧޤ

CK-MBӥȥݥ˥TͤˤͭդѲǧޤǤ

TA(E-OJ-01)Ϸ򹯤ʼǯˤƿǽΨ򤢤¡ξ֤뤳Ȥ狼ޤ


ʾ塢Ѥλ

른ʤϥɤؤο¡ΤѤޤ

ƯϲʳŪʼ¸ˤɽƤ褦Ǥ

ɡԥ󥰸륢꡼ȤϡդʤФʤޤ

ܤǤϤޤΤƤʤ른ʤϥץȤȤƼ뤳ȤǤޤ

ܤǤϥΥȡ TORCH˥른ʤ۹礵Ƥޤ

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ϤäȼѤơ䤨ǺؤΤ⡣

ȿŪ䤨ڤäƤޤˡ

ܿͽоݤˤ˥ӥǥ󥹡



˽ϪκݤΡ(Emblica officinalis Gaertn.)ʪݼ褹뤳Ȥˤɽ̲βȷήβݥಽܻ

Effect of Amla(Emblica officinalis Gaertn.) Etract Ingestion on recovery Body Temperature and Blood Flow Following Cold Stress.

Abstract
Ūθϡ䤨ҴʽоݤȤ˽Ϫɽ̲ȷήβ٤ɾ뤳ȤǤ

ˡ32ͤΥܥƥоݤ˥ಽܻηǹԤޤоݤˡޤॵץȤ⤷ϥץ饻ܤƤ餤ޤ2֤Ǥ˽Ϫɽ̲ȷήβˤĤɾޤ

̡ʪǤɽ̲ȷήͭդʺǧޤ

ͭץȤˤϴ˽Ϫɽ̲ȷήβ¥ʤޤη̤ϥʪ䤨פ򴶤ƤͤˤͭפʥץȤǤǽ򼨤Ƥޤ


Introduction
ܽ1/3䤨򴶤ƤȸƤޤΤۤ䤨פ򴶤礬⤯ǯ𤬾夬ˤĤäޤʰά

Amla(Emblica officinalis Gaertn.)ϲɴǯˤϤäƽפڤȤΤƤޤǮ䥤ɤ֥ޤΰǮǤϰŪڤǤ˭٤ʥӥߥC˥gallic acidellagic acidȤäݥեΡ롢륻ȤäեܥΥɷϤޤǤޤŪŤǡϲΡ䲫աʤɤФƻȤޤʰά

ϹʪȤƤ¦̤äƤޤ13in vitroǥϲƥҥɥ饸⤷ϥѡɥ饸Υ٥󥸥㡼ȤƯǽƤޤ14,15


о
20-40Фη򹯤ܿͽ85ͤȤޤ

Table2˳ʥե䤹Ǥ˥Ƥ硢ǽʤɤǺθˤŬȻפ줿硢θǥ륮ФǽʤɡˤϽޤ85桢32ͤоݤȤʤޤ٤αưåȡῩ򤱤褦ˤꤤޤ륳롢䥨ʥɥ󥯤ʤɤݼ褷ʤ褦ˤꤤޤҡ䥭礦¬ޤǤ1,2ϵƤޤ


Ĵ٤ץ
2ץƤ餤ޤ1ĤΥץ˥ʪ200mg˥ǥȥ7mgˡƥ륷2mgˡǡ1mgˤޤޤƤޤץ饻ܷΥץˤϥǥȥ207mgˡƥ륷2mgˡǡ1mgˤޤޤƤޤ


ά


¬ˡ
︡Ԥ25٤μǰŤˤƤ餤ץȤ⤷ϥץ饻420mg200mlοƤ餤ޤ90ʬ塢μ153ʬξ򤵤餷Ƥ餤ޤ餷ľ塢5ʬ塢10ʬɽ̲Ʒή¬ꤷޤ

ʲά


̡
32ͤ︡ԤXYȤʬޤæԤʤɤX17͡Y14ͤӤޤ򺹻ηȤ뤿ᡢ1ԥꥪɤǤX˥Y˥ץ饻ܤƤ餤1֤Υ󥿡Х֤ΤX˥ץ饻ܤY˥Ƥ餤ޤ

Table331ͤ︡ԤΥǡǤǯνš̴찵ĥ찵̮ɽ̲ήʤɡξǺǧޤǤ


裱ԥꥪɽλ
Fig.2ϴ˽Ϫɽ̲β򼨤ΤǤ˽Ϫ塢μؤɽ̲ץ饻ܷᤤȤ狼ޤ5ʬ¬ǥ2.370.09ץ饻ܷ2.000.17ξ徺ǧ졢ξ徺κͭդʤΤȤʤޤؤηή˴ؤƤϡǤ5ʬλ12.330.69Ȥʤꡢץ饻ܷ10.070.59Ӥͭդ˹⤤ΤȤʤޤ

2ԥꥪɽληή̤餫˰㤦ΤȤʤäᡢ򺹻η̤ɾǤΤǤϤʤȷդޤ
ѤϳǧޤǤ


Discussion
˥ϥӥߥC䥬å顼åʤɤȤäʪޤǤޤɽ䤹Ȥˤηɼ̤ϥɥʥΥ륢ɥʥᥫ˥ˤäƤΤǤ

ơ˽Ϫ10ʬ̤ˤǤϤηɼ̤ΤNEʥΥ륨ԥͥե󡩡ˤ浯ȸƤޤȿϹʪˤäƴˤ䤫Ȥʤ뤳Ȥ狼äƤޤ϶ϤʹѤͭƤꡢκѤˤäɽ̲βήäƤΤ⤷ޤ

¾Υᥫ˥βǽȤNOƯޤNONOSNO󥿡ˤˤäƳɽηɼ̤˴Ϳ油ξ徺⤿餹ȤʬäƤޤNOSϥݥեΡˤäƳޤäơݥեΡϷή䤨ξɾ¤ǽޤ

ʰάKarazawaϡߥʷ쾮ĶŽѤȷʿд˺ѤΤˤ她ȥ쥹ˤ油β᤿Ȥ𤷤Ƥޤ35Ϥη̤ˤ쾮ĶŽѤ油ˤϴϢ뤳Ȥ狼ޤ

桹θǤϥcorilagin䤽¾ellagitannin componentsin vitroǥȥӥˤ쾮ĶŽˤAPTTPT֤Ĺ뤳Ȥ狼äƤޤ36

ĤޤꡢˤϹѤȤȤǤellagitanninκѤˤꥢˤϴ˽Ϫɽ̲βѤȹͤޤʰʲά



ʾ塢Ѥλ

ܤΥץǡ餬äΤϤۤ¿ޤ

Ǥ⤪ǤΤ

Υȡ TORCHǤϤʤǤ礦

ݥեΡ40ʾɸಽ줿 ۹礵Ƥޤ


ޤΥȡˤϡΤۤ¡η򹯤ɤ른ʡ
ȥ쥹ɾΤۡ꡼Х롢ޡȥϡ֤Υĥ۹礵Ƥޤ

ҡʤȿŪǮɤ餻Ʋ

TORCHϥޥǤޤ
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οˤΤܤ륢ϡڹɤͽɤ򥵥ݡȤ̼¤⤷ޤ


ͤоݤ 500 mg Υ 12 ˤ錄ݼ褷η줷Ȥ


ɷϤΥꥹեͭȻפͤФˡͭפʸ̤⤿餹ǽ롢𤷤Ƥޤ


PMID25756303 http://www.ncbi.nlm.nih.gov/pubmed/25756303









̥쥹ƥ򲼤


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η򤪤롣


餬ڹɤǾɤޤͤװǤ뤳ȤϤΤΤȤꡣ



Ĥޤꡢ꤬ǡȥ쥹¿ϡ饨򤴸Ƥ



ˤͭѤ ּ֤β̼¡ ˤĤơ


ٻ븦ϡͥåȤΤʤǤưפ˸Ĥ뤳ȤǤޤ


ۤˤ⥳顼롣


ǧεǽ롣


ä򸺤餹ȤԤǤ롢ʤɡ


⤽ΤϤ⤷ޤ


β̼¤ϥӥߥá˥󡢥󡢤Ȥäʬ¿ޤǤ뤫Ǥ



ȤХӥߥ ϡ˦ϷޤȱϤ뤽ιѤ줿⤷ޤ


ȤǡΥ饨ץȤϾʤ褦Ǥ


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ץȤϤ򸫤


ͭʬδͭΨ Τޤ礦


ȤФʸɽ

Σ ѥ 300 (ͭʬɽʤ)

Σ ѥ 200 (˥40ʾ)



ʤʤӤʤ Σ ɤǤ


ȤХꥫΥ٥Ǥϡɽˤܡ


Amla Extract ( ޤ Amla Powder )


Tannins Ǥ




ʤߤˡƬΰʸѤƤΤϥ˥ 60 ʾɸಽ줿饨CAPROS ȤɸǤ




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٤ƤΥץȥ᡼٥ƤФơ¤Ǥ뤳ȤꤦФǤ


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ȤϤ줬񤫤ƤʤΤϺΤǤ


ץȤؤδԤȤϡͭʬˤۤʤޤ󤫤顣


饨äɤޤ礦



β̼¥ TORCH ۹礵Ƥޤ


˥ 40 ɸಽ줿Τ 3ץ 300


ޤ TORCH ˤϡ۴ķϤη򹯤ԤǤۡ꡼Х롢ĥ顢른ʥ۹礵Ƥޤ


¡η򹯤ꤿϡTORCH ƤƤߤƤϤǤ礦
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른 ϥ˰ļڤ餫Τ륨Ǥ


ǤϿ¡˴ط뤵ޤޤĴǤμפʸȤϰ̤ˤޤ


Ͽ¡줵붯ѤǤϤޤ


ưʪǤθǤ͡ʥᥫ˥ǿ¡뤳Ȥ𤵤Ƥޤ


ڤ˻Ǥ򶡵뤹뤳ȤǤο¡ݸѡ(1)


򲼤Ϥ餭ޤϡڤμ̤å뤳Ȥˤݸѡ( ϱѻѡƱϺѤȤ⤤ ) (2)


Ȱ̥쥹ƥ򸺤餹̥쥹ƥ䤹ȤǤݸѡ(3) (4)


ư̮μ̤ˤ䤫ˤȤɤݸѡ(5)




׾ˤƤϤ


ɤιٯ (䤯) Ĥ褦ʶˤߤФͭѤǤ롣


¡ΥꥺﲽΤˤΩġ


÷Ȥˡȯĥھɤνˤʤ롣(ʾ 6)


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ѤˤĤ


른ʥ 500 1 3


26 ݤĤŤƤѤϤʤäȤΤȡ(6)





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ܤΥץȤǡ른ʥ۹礷ƤΤϡߡΥȡ TORCH Τ褦Ǥ

TORCH ˤϡ른ʥޤͤĤοʪ۹礵Ƥޤ


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֥른ʥ 200 ӡ


֥ĥ饨 200 ӡ


֥ۡ꡼Х륨 150 ӡ


֥饨 250 ӡ



ĥƬǾѤΥץȤǤΤƤޤ۴ķϤη򹯤⥵ݡȤ뤳ȤʬäƤޤ


ޤۡ꡼Хϥ󥿥η򹯤򥵥ݡȤ륢ץȥǤ



ƥ饨ϥӥߥCݥեΡޤǤޤ


Τɤˤ۴ķϷ򹯤򥵥ݡȤȤߤޤ



Υȡ TORCH ϡ
Ǿȿ¡󥿥η򹯤롢ŪʥץȤȤȤˤʤ褦Ǥ
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TORCH AmazonŷǤǤޤ
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1Dwivedi,S.,Chansouria,P.N.,Somani, P.N.,and Udupa, K.N. (1987). Influence of certain indigenous drugs on the Prostaglandin E like activity in the ischemic rabbit aorta. Indian Drugs,24 (8), 378-382.
2). Singh, N., et al. (1982). Mechanism of cardiovascular action of Terminalia arjuna. Planta Medica, 45:102-104.
3). Tiwari, A.K., Gode, J.D. and Dubey, G.P (1990). Effect of Terminalia arjuna on lipid profiles of rabbits fed hypercholesterolemic diet. Int. J. Crude Drug Res. 1, 43-47.
http://www.researchgate.net/publication/232052375_Effect_of_Terminalia_Arjuna_on_Lipid_Profiles_of_Rabbits_Fed_Hypercholesterolemic_Diet
4). Khanna, A.K Chander Ramesh and Kapoor, N.K. (1996). Terminalia arjuna : an Ayurvedic cardiotonic regulates lipid metabolism in hyperlipaemic rats. Phytotherapy Res. 10, 663-665
http://www.researchgate.net/publication/230186202_Terminalia_arjuna_an_Ayurvedic_Cardiotonic_Regulates_Lipid_Metabolism_in_Hyperlipaemic_Rats
5). Tripathi,Y.B.(1993). Terminalia arjuna extract modulates the contraction of rat aorta induced by KCI and Norepinephrine. Phytotherapy Res.7,320-322.
http://onlinelibrary.wiley.com/doi/10.1002/ptr.2650070413/abstract
6) Dwivedi, S. and Agarwal, M.P. (1994)Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug, in coronary artery disease. J. Assoc. Phys. India, 42:287-289.
http://www.ncbi.nlm.nih.gov/pubmed/7741874

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