ȿռԤΤ
ץ

ޡȡץȾϤޤӥͥޥ󡢱̿ĩढʤΤ긵ء

ƥ SWITCH

򹯤ʼǯ︳ԤоݤȤ󥳤ûݤǧεǽФ̰¸̤θƤ

The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers.

PMID:11026748
https://www.ncbi.nlm.nih.gov/pubmed/?term=11026748


Abstract
Rationale:祦եʥ󥳡ˤĹ뤳Ȥˤꡢǧεǽ뤳Ȥ狼äƤƤޤ

󥳤ûŪѤˤĤƤϤϤäȤ狼äƤ뤳ȤϾʤ֤Ǥ

ǶθˤꡢCR(Cognitive Drug Research)ˤ¬ꤵ줿4Ĥǧι(Ϥ®١ϤΤ®١Τ)ǧεǽѲ¬ꤹΤͭѤǤ뤳Ȥ狼äƤޤ


Objective:θǤϥ󥳤CDR4ܤΤʸ̤⤿餹ɤɾޤ


Method:θܥץ饻ܥȥ򺵻ηǹԤޤ

20ͤ︳Ԥоݤ˥ʪ120mg,240mg,360mg⤷ϥץ饻ܤƤ餤ޤ

ǧεǽCDRԥ塼ƥȤˤ1,2.5,4,6֤¬ꤷˤǧεǽ4ܤˤĤɾޤ


Results:ץ饻ܷӤƥ󥳤¿ͭդѲǧޤ

ǺǤϤäȤΤ̰¸Ϥ®٤βǤ

240mg,360mgɤͭդʲǧ졢2.5ָǺǤϤäꤷ̤ꡢ6ָǤ⤽θ̤ϻ³Ƥޤ


Conclusion:θǷ򹯤ʼ㤤︳ԤоݤȤǥˤϤλ³Ūʲǧޤ


ʾѤλ

Υ祦եϡ

Υå SWITCHCOOL SWITCH

2ץ˥祦ե120ӡ

äơǾǽΤιͻCOOL SWITCH ϥꥫͻˡХѡۥե륻۹礵Ƥޤ

Ȥ߹碌ˤϡɹƯԤǤޤ

ϤȵϤɤΤǤϤʤǤ礦

ޥ
https://www.amazon.co.jp/
ŷ
https://www.rakuten.co.jp/

ʡʵ㲼򼫳Ф뤳ȡˤΤǯܿͤεϤФƦۥե륻θ

Soybean-Drived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

PMID: 21103034

ʢѤϡˤơ
https://www.ncbi.nlm.nih.gov/pubmed/?term=21103034


Abstact
Ʀۥե륻Ʀ쥷󤫤ۥե륻ǤʤΤǯܿͤǧεǽФƦۥե륻θ̤餫ˤ뤿ܻԤޤ

䵭Ϥ԰¤Τ78ͤǯ(5069)˥˷᤿Ʀͳۥե륻(100mg,300mg/)⤷ϥץ饻ܤ6Ƥ餤ޤ

̤ȤƦͳۥե륻ȤǷոͤ찵̮ʤɤѲϤʤѤǧޤǤ

λǥ㤫ä︡Ԥǥۥե륻Ȥˤ뵭Ϥͭդʲǧޤǥץ饻ܷǤѲޤǤ


Introduction
ۥե륻Ǿ¿¸ߤƤιʪǤ

ۥե륻зϤؤαƶΤƤޤ1-5

ꥫ䲤Ǥ׾ǵͳۥե륻ǯ︳ԡ6-10Ϥ䥢ĥϥޡ¤δԡ8,9ϡǯˤ뵭㳲(AAMI)δԡ10ϤǤǧεǽβ뤳Ȥ狼äƤޤ

ͳۥե륻BSEʶ¡ˤΥꥹ뤿ᡢߤǤϻѤƤޤ

Ʀͳۥե륻BSEΥꥹʤᤵ˸椬ԤƤޤ12


ʰʲ1995ǯGindin餬AAMIΤǯ︳ԤФƦͳۥե륻(300mg/ 3)εϲ̤𤷤ΤǽǤ17

CrookƦͳۥե륻(300mg/12)AAMI︳Ԥǵϲǧ줿𤷤Ƥޤ18

¾Ʊͤ𤬤ޤܿͤоݤȤΤϤޤǤ

桹2005ǯAAMIǯ︳ԤФƦͳۥե륻Ƥ餤DWR(delayed 3words recall)ƥȤͭդʲǧޤ21

θ١ȤƲ桹ϵ԰¤Τܿǯ︳ԤоݤƦͳۥե륻(100mg⤷300mg/6)θ̤ܻηǷײ褷ޤ

Ϥˤ԰¤Τ︡ԤФ뤿RBMT(Сߡɹư)Ѥޤ22

ϵϤɾ˥եƤǤ

6֤ΤΤ3Υեå״֤ȤꡢߤΤƦۥե륻θ̤뤫ɤĴ٤ޤ


ˡ
оݡʰ
50-69Ф߽˽Ǥ䵭Ϥ԰¤ΤоݤȤޤ

ޤ︳ԤεϤ㲼٤ɾäHDS-RDWRιܤˤĤĴޤ

RBMTHDS-RMMSEʤɤѤ꡼˥󥰤Ԥޤ

η̡700ͤΥܥƥΤ78ͤޤ

5ͤɥåץȤ̤Ȥ78ͤȤʤޤ


ǥ
θϥಽܻηǹԤ︳Ԥ3Ĥηʬޤʤ줾28ͤġˤɤηǤʿǯ̡ǯҤΥʤɤǰ㤤ϤޤǤ(ɽ1,5)

꡼˥󥰤ԤäƣˣĤη˥ץ饻ܡۥե륻100mg/ۥե륻300mg/򣶥Ƥ餤ޤ

θ夵ˣвѻԤޤ

飶ܡвѻ壳ܤɾԤޤ

ǧεǽɾŪHDS-RMMSEޤĵʬɾGDS򡢤ưɾ뤿˷ոǢԤޤ

ˡRBMTEMCˤĤƤвѻɾԤޤ

RBMTˤĤ
RBMTϵϤˤĤƸڤƥȤǤ22

12ܤʤꡢĿͤνͤ̾ʹˬ줿ȤäεˤĤɾޤʰʲά

HDS-RĹëˤˤĤ
HDS-RǧξɤοǤܤǤ褯ѤƤɾˡǤ
3021ͤ㤤ǧξɤβǽޤ

桹ϤΤDWRιܤܤޤ

ȤΤϡͽƦۥե륻Ϥιܤ˺Ǥ̤äΤǤ21

DWRȤΤϡ︳Ԥ3ĤδϢΤʤñ󼨤ȤǤäƤ餦ȤˡǤ

EMCﵭåƥȡˤˤĤ
EMCϵ㳲ˤǤξ㳲ΤƤɤɾˡǤ28ǵ䤹˴ؤپ13ܤɾޤ



ոǢۥե륻λľ(6)λ3ǹԤޤ찵̮ȤäХ륵ˤĤƤɾޤ




֤̤ơۥե륻ץ饻ܤȤ˴ϢѤϳǧޤǤ

ɽ2,3˼褦ˤ٤ƤηǷ컻ӷͤǤͭդѲϳǧޤǤ
Х륵ǢǤѲϤޤǤ(ɽ4)


ǧεǽ
RBMTǤΥѲɽ5˵ܤޤ

3٤Ƥǥͭդʾ徺ʲˤǧ졢λǤƦۥե륻ȥץ饻ܷȤδ֤ˤͭդʰ㤤ǧޤǤ

RBMT19ʾäRBMT19ʲäˤƤͭդʺǧޤǤ

HDS-RˤĤƤ3٤ƤǾ徺ʲˤǧ졢3֤ǤͭդʺǧޤǤ

3ηвѻ֤ΤΤץ饻ܷΥοޤƤޤۥե륻100mg/300mg/ɤˤƤ⤤ݻƤΤǤ

HDS-R⥹ǤHDS-Rͭդʰ㤤ǧޤǤHDS-R١λ㤤ǤƦۥե륻ͭդʥβǧ줿ΤǤ

3(A)HDS-RDWRܤ㤫äΤΤǤ

Ʀۥե륻Υ٤ͭդ˲3ηвѻɾƦۥե륻100mg/300mg/ɤˤƤץ饻ܷȤͭդʰ㤤ǧޤ

DWRˤ륹βηϡΥȡ륹βȹƤޤ

ΤȤϡȡ륹βϼDWRܤβˤäƤ⤿餵ȤȤ򼨤Ƥޤ

¡HDS-RΤ¾ιܤǤͭդѲǧޤǤ

ǤѲϾΤǤϤޤMMSEǤDWRܤˤĤƤƱͤηǧޤ

Ʀۥե륻Ǥ٤ƥͭդʲǧޤβ٤ϥץ饻ܷӤͭդʰ㤤ФۤɤΤΤǤϤޤǤ


ʰȴ
դλפФ٤ǧξɤʳǤɾͭѤǤȸƤ30,31Ϻθ̤ǤƦۥե륻ǧξɤΤμŤȤͭǤȻ򼨤Ƥޤ

RBMTˤĤƤϡǧΤ̾ȤδϢդʤɤιܤۥե륻ˤäƥȤ𤬤ޤ18,19

󡢤Τ褦ʲʤäĤװȤơ︳Ԥ餹Ǥ˹⥹ޡƤͤǤꡢʾβʤäǽޤ

桹Ϻ󡢷ۥե륻ͤ¬ϹԤޤǤĤʪư֤θۥե륻®䤫˵ۼ졢BBB(Ǿ)̲ᤷǾã뤳ȤǧƤޤ32

åȤѤƦۥե륻ǾɤľͿ븦Ǥ⵭ϤβǧƤ15ϡƦۥե륻Ǿľܸǽޤʰʲά

ʾѽλ

ơҤȯ䤵Ƥ륹å SWITCHޤ COOL SWITCHϡ
ǯ 50аʾˤΡʪ˺פФɤȤ뤫⤷ޤ

ʬƦ쥷ʪʥۥե륻ͭ100mgͭƤޤ

¾ˤ⡢Ǿη򹯤˴Ϳɤϡ֤ġ

祦աͻ(COOL SWITCH ϥꥫͻ)ХѤޤޤƤ뤫Ǥ

Amazon
SWITCH
switch %282%29

COOL SWITCH


ǯ ADHDˤĤƤκǿ椬𤵤ޤ


ADHDǾ礭ˤ鷺ʺ絬ϸdzǧ
http://www.afpbb.com/articles/-/3118188?cx_part=txt_topics


Υ󥯤Ϥʸ
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis


θƧޤADHD βפԤǤ륵ץȤ򤴾Ҳ𤤤ޤ礦


ޤ֥ǰҲ𤷤ΰʸ򤪤餤ɬפ뤫⤷ޤ


Lyon MR, Cline JC, Totosy de Zepetnek J, Shan JJ, Pang P, Benishin C. J Psychiatry Neurosci. 2001. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. 2001 May;26(3):221-8.


ޤ


ADHD Ф륢ꥫͻȥ祦եθ

ˡΤ317ФޤǤ ADHD οǴ (DSM-) ˳Ƹ36ͤоݤȤƸԤä

Ƹˤϥꥫͻ 200mgȥ祦ե 50mgäץ 2γ/ʢ 4Ƥ餤Ϥ 2ָ 4ָɾԤä

ɾˡȤƤϡͿȸǿƤФĴԤADHD μפʾɾ (ȿŪưؽ㳲¿ưư԰ҲŪꡢ԰) Ѳӡ ADHD οǴ (DSM-ʡɾ١CPRTconners parent rating scaleˤʤ) ѲˤĤƴѻ

̡ꥫͻȥ祦եäץ߻ϤƤ2ָ塢嵭7Ĥμ׾ɾΤȿŪưˤĤƤ 64%λƸǡؽ㳲ˤĤƤ 56%λƸǡ¿ưưˤĤƤ50%λƸDzǧ줿

4ָˤϡ7Ĥμ׾ɾ٤Ƥͭդʲǧ줿

ޤ7Ĥɾ˾Ȥ餷ƤߤƤ24ɤλˤƤ⤹٤Ƥɾͭդʲǧ줿㤨СDSM-դιܤǤ 2λ 39%λƸǡ4λǤ 75%λƸDzä

ѤˤĤƤϡưưȽǤ줿Ƹ2ͤ

ޤ꥿ʻѤƸȯƬˤäƸ줾1ͤĤͻȥ祦դαƶǤΤɤǤʤä


Ѥλ



ϡǤ

ʸ˽񤫤줿 Ginseng extracts ιܤǽҤ٤Ƥ롢Ƥ


ȴ
Ginsenosides have been shown to possess neurotrophic effects. The ginsenosides Rb1 and Rg1 have been shown to potentiate the effects of nerve growth factor, which is a critical endogenous neurotrophic substance.
This suggests that long-term administration on ginseng extract may have the potential to promote the growth of underdeveloped brain regions in those with ADHD.



󤷤ޤȡʤޤ
ginsenosides ϿбܺѤͭƤ



ginsenosides Ȥϡͻ䥢ꥫͻ˴ޤޤʬǤ

ginsenosides Rb1Rg1ϡĹҤθ̤¥ʤ롢Ȥޤ


Ĥޤꡢꥫͻ⤷ϹͻʪʥˤĹݼ褹ȡ

ADHDδ̤ȯãǾΡʬŪĹ¥ʤǤǽ롣


äơADHDΩƤΰĤȤƤϡ

ûŪˡޤĹŪˤ⡢

祦եܥꥫͻޤϹͻȤ߹碌ɤΤǤϤʤǤ礦


ǤϡͤޤǤˡɤʿͻ㤨ɤǤ


ˡĴ٤ϡ嵭ڳʬޤޤƤۤݤǤ


ܤƤڥץȤΥ٥ۤˤϡֳʬפϽ񤫤줪ޤ

٥ؤɽϡ(ʤȡ)ˡ˿줫ͤʤΤǤ


ǡ
ʬˤĤƤϡ᡼ľܿҤͤ뤫᡼HPκܤ̤ȤɬפǤ



ȤСȯ䤹 SWITCH åˤϡ嵭 (ɬפʬ̤ȳʬ) ͻȥ祦դޤޤƤ褦Ǥ

ƥꥫͻä COOL SWITCH 륹åƱͤǤ


ưͤϡꥫͻä COOL SWITCH 礤䤹⤷ޤ


åȥ륹åˤϡ
ADHDɤȤۥե륻󡢥Хѥ⥨۹礵Ƥޤ


ޥŷǼ뤳ȤǤޤ

ѤƤߤƤϤǤ礦

祦եǾɤͳϡή䤹ǤϤʤ褦



ߥåؤ J. V. Smith ᡢ Y. Luo ˤ륤祦եΥӥ塼򤴾Ҳ𤷤ޤ礦


֥ ӥ ȥ饯 ( 祦ե ) ʬҳŪᥫ˥˴ؤ븦
Studies on molecular mechanisms of Ginkgo biloba extract Appl Microbiol Biotechnol (2004) 64: 465472 J. V. Smith . Y. Luo




祦եˤϣĤʬꡢ餬ˡѤäƤȤȤ餳Υӥ塼ϻϤޤ롣


1)ƥڥ


2)եܥΥ



1)ƥڥϼʬव롣


a)󥳥饤 ABCJM


b)ӥХ饤



a)󥳥饤ɤθ


󥳥饤ɤϷ쾮ij (PAF) Υ󥿥˥Ȥǡ쾮ijӶŽ˳롣ˤäƷս۴Ĥ ס1


󥿥˥ȤȤϤѤ˳ʪ (ɹʪ)


Ĥޤꥮ󥳥饤ɤϷηɤȤԤǤ롣



2)եܥΥɤθ


եܥΥɤϹѤȯ롣

եܥΥɤ˧ĤŷˤäƹƤ롣ˤäơҥɥ饸ˤȿ䤹ľŪ٥󥸺Ѥͭ (2)


ҥɥ饸ϥե꡼饸롣


ҥɥ饸¾ʪȿ䤹ѥģΣĤ롣


˥塼ʪǤ˰»ûФƤ⡢Υ饸뤬᡼Ϳ롣


եܥΥɤϤĤޤ˥塼뤳ȤԤǤ롣





SOD ( superoxide dismutase ) Τ褦ʹѥȯ륿Τ褦ʹʪä (3)(4)


SODȤФΥҥɥ饸̵ǤΤȡ


ȤSODϲȼƤޤ


եܥΥɤSODä롣




եܥΥɾο prooxidant transitional metal ions (㤨Fe2+) ȷ礷ƥ졼ȴĤ (3)


ˤ꿷ʥҥɥ饸˳ (2)(5)


ŴϻӤ䤹


ŴǤƱǤ


嵭ϡեܥΥɤŴȿƻɤȤ






ǤϤʬޤ।祦եμפʸ̤ˤĤơ



ե꡼饸롢ȥ쥹ˤĤ


ե꡼饸륹٥󥸥㡼ѤäƤ

ROS ( reactive oxygen species ) ȿǻ٤򸺾 (6)(7)(8)


ROS ( Ǽ ) Ȥϥե꡼饸롢ǤΡ


祦եϤ򸺤餹ȤϹѤˤĤƤ



ȿ (6)


ȿȤϡλϢȤݤΤȡ


뤭äǿǤȴ줿ϡե꡼饸Ȳ


줬ϢλϤޤꡣ


饸벽¾ʪŻҤå饸䤷Ƥ椯


饸ϷʻοǤĤĤ̤


Ȥ褦ˡȿȤϡлӲݡ


ƥ祦եϤϢȿƯͭ롣


ʤߤˡ


ӥߥE饸򸵤᤹ʪ


ӥߥŤΥץݼ¿̤ˤʤ䤹ä夲ͤʤΤդɬס


λɤΥץȤ֤ʤ顢եܥΥɤɤǤ礦




2 ȥ쥹


PBR ( peripheral-type benzodiazepine receptor ) ȯ򸺤餹 (6)


PBRȤϡ٥󥾥ԥΤΤȤǥιˤΤΤȡ


¿¸ߤƤ롣


祦եϥ̤򸺤餹褦Ǥ롣



¸ԲķʥۥǤϤΤΡΤ͡ʾ㳲ۥǤ⤢롣


ȤХȯʤȥ쥹ϡϤѽ̤ͤޤ󡣳ϤΥ˥塼󤬻ǤƤޤ


ϤˤϥμΤ¿ޤ


ʢ¿ơ饹ȥ쥹ϤҤȤ餻롣Ϥޤ̤ʵˡ


ϤΤΥȥ쥹ȿؤȡָƤӤ״ﴱǤ뤿ᡢ̤ΩĻȤߤǤ


ʥϡŪʥȥ쥹ϡ˳ϤΥ˥塼ֶʳפؤɤߤͤޤ


ֶʳפȤݤϥ˥塼󤬻ǤȤߤΤҤȤĤǤ


˻ɷ㤵줿˥塼˥륷।̤ή˥塼󤬶ʳ֤Ȥʤꡢư򵯤̤ơǤ롢Ȥݡ


ϤεǽˤĤϤΤȻפޤǰΤᡣ


Ϥϵ夵국Ƥӵꤹ뵭ﴱǤ


ޤϤΤΥȥ쥹ȿؤž륹åǤ⤢롣


äƳϤͤǤäƤ˥塼󤬿ľꡣ




ǾΥΥߥ ( MAO ) 㲼 (9)


MAO ( Υߥ󥪥 ) ˳ǾΥɡѥߥǻ٤夲롣


MAO˳ϡꥫǤϹĺޤȤƤȤ뤳Ȥޤ


줹ʤ祦եιĺѤ򼨤Ǥ




3 ˥塼Υݥȡؤκ


˥塼Υݥȡθ (10)(11)(12


ݥȡȤϥץव줿˦λǡ˦μȸ븽ݤǡ˥塼ǸΤҤȤġ




4 ǧεǽؤθ


祦եϥߥɥ١Ȥ𤵤Ƥޤ


в˦˦ˤ륢ߥɥ١ζŽ (11)


ջ׷ǽϤưʪˤ뿷νȥ쥹ؤα䵤ʬѲȤäҤФͭ (9)(13)


ģΣ»۾ʥΥѥ뤳Ȥޤ


ȤǾˤƤϡѥ¤βǡ衢¦ޤꤿޤ٤ʬˤभФȤʤ뤳Ȥޤ


۾ʥѥƱ֤夷ȲƤ椯


βϥߥɥ١ȸƤФޤ


ߥɥ١ϥĥϥޡ¤θΤҤȤĤȤ⸫Ƥޤ


ߥɥ١夷˥塼Ϥ䤬ƿ夷Ǥ뤳ȤʬäƤޤ


祦եϤοʳˤ˥塼Ȥ⤢ޤ


嵭ϥ祦եߥɥ١ηȤǤ


ʤߤˤΥӥ塼ˡ祦եεϲѤ𤹤ʸΰѤϤޤ󤬡βǽ򼨤ʸ򸫤Ĥ뤳ȤϤǤޤ


ʬҥ٥ǤϡȤ NDMAΡĹ˴طΡˤΥΥåȥޥ˥祦եͿϤä𤵤Ƥޤ




5 աήɤؤκ


쾮ij PAF ̤ˤǾβ (10)


ͳд˰ EDRF (Stimulation of endothelium-derivedrelaxing factor) λɷˤư̮̮Ӻٴɤν۴IJ (14)


ɤΤäȤ¦¸ߤ͡ʪʬ礷ޤ


EDRF (NO ) ⤽ΤΤҤȤġ


ǤϷɤдˤ롣


祦եήɤȤΤϤΤȹͤ롣




5 ãʪؤκ


ǾΦ1-ɥʥΡ5-HT1A ( ȥ˥ ) ΤӥॹΤǯˤ븺ͽ (6)


Ϥιȥ󥹥ݡμߤ (6)


ʥץ˦Ф줿륳ϡʥץ˦μΤȤǡ®ʬ򤵤ޤ 󥨥ƥ顼ˤäƥȿݻˡ


ʥץϿã򤹤뤿˥륳١ͭʤФʤޤ


˥塼ϥ륳θǤ륳ޤΤǡʬ򤵤ƼϤɺ򡢺١ʥץ˼ꤳɬפޤ


Ϥιȥ󥹥ݡȤϡ饳μ߸ΤȤǤ


Ĥޤꥤ祦եϥ륳䤹褦ǤʥΥꥵΨ夵ˡʤʤߤ˹ͻˤ⤳Ưޤ


륳ϡηؽư̲˴طãʪǤ뤳ȤϤΤȻפޤ




7 ȥ쥹ѡȯؤκѤʤ


ϤΥ륳ɼΤΥ쥮졼˳ (6)


祦եϡȥ쥹ؤϤȤ


ϤΥ륳ɼΤθ򤯤ȤȤκѤϡιƱͤƯ


륳ɼΤȤϥμΤǤ


μΤγȤϡΤΥȥ쥹ȿؤڤؤ뤿˽ס


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ΰҤž̤Ĵ᤹롣η̡˦ι֤äȥ쥹򶯲ã륳̤(15)


DNA佤˦ˤ뵡ǽ˴ؤ륿ѥѲ˱ƶ򤢤DNA»(15)


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ۤˤ⡢祦եϹ⻳¤ͭǤȤ⤢롣


줬̣ΤϻǤμ߸Ψ夲ȤȤǤ


ΤʤǤǤμߤθ֤ϤӤޤ


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ɺѤǾ㳲Фݸ (16)


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祦եϼä˥塼褦Ǥ롣






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祦եȤ߹碌¸ǤϡADHD⤵Ƥޤ


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References
(1)Defeudis FV (2002a) Bilobalide and Neuroprotection. Pharmacol

Res 46:565568

(2)Zimmermann M, Colciaghi F, Cattabeni F, Di Luca M (2002)Ginkgo biloba extract: from molecular mechanisms to the
treatment of Alzheimer's disease. Cell Mol Biol 48:613623

(3)Gohil K, Packer L (2002) Global gene expression analysis identifiescell and tissue specific actions of Ginkgo biloba extract, EGb761. Cell Mol Biol 48:625631

(4)Oken B, Storzbach D, Kaye J (1998) The efficacy of Ginkgo bilobaon cognitive function in Alzheimer disease. Arch Neurol55:14091415

(5)Ni Y, Zhao B, Hou J, Xin W (1996) Preventive effect of Ginkgobiloba extract on apoptosis in rat cerebellar neuronal cellsinduced by hydroxyl radicals. Neurosci Lett 214:115118

(6)DeFeudis F, Drieu K (2000) Ginkgo biloba extract (EGb 761) andCNS functions: basic studies and clinical applications. CurrDrug Targets 1:2558

(7)Lien E, Ren S, Bui H, Wang R (1999) Quantitative structure-activityrelationship analysis of phenolic antioxidants. Free Radic BiolMed 26:285294

(8)Smith J, Luo Y (2003) Elevation of oxidative free radicals inAlzheimer's disease models can be attenuated by Ginkgo bilobaextract EGb 761. J Alzheimer's Dis 5:287300

(9)Pardon M, Joubert C, Perez-Diaz F, Christen Y, Launay J, Cohen-Salmon C (2000) In vivo regulation of cerebral monoamineoxidase activity in senescent controls and chronically stressedmice by long-term treatment with Ginkgo biloba extract (EGb761) Mech Ageing Dev 113:15768

(10)Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, QuirionR (2000) The Ginkgo biloba extract (EGb 761) protectshippocampal neurons against cell death induced by betaamyloid.Eur J Neurosci 12:18821890

(11)Luo Y, Smith J, Paramasivam V, Burdick A, Curry K, Buford J,Khan I, Netzer W, Xu H, Butko P (2002) Inhibition of amyloidbetaaggregation and caspase-3 activation by the Ginkgo bilobaextract EGb761. Proc Natl Acad Sci USA 99:1219712202

DeFeudis FV (1998) Ginkgo biloba extract (EGb 761): fromchemistry to clinic. Ullstein, Weisbaden, Germany

(12)Smith J, Burdick A, Golik P, Khan I, Wallace D, Luo Y (2002) Antiapoptoticproperties of Ginkgo biloba extract EGb 761 indifferentiated PC12 cells. Cell Mol Biol 48:699707

(13)Cohen-Salmon C, Venault P, Martin B, Raffalli-Sebille M, BarkatsM, Clostre F, Pardon M, Christen Y, Chapouthier G (1997)Effects of Ginkgo biloba extract (EGb 761) on learning andpossible actions on aging. J Physiol 91:291300

(14)Smith P, Maclennan K, Darlington C (1996) The neuroprotectiveproperties of the Ginkgo biloba leaf: a review of the possiblerelationship to platelet-activating factor (PAF) J Ethnopharmacol50:131139

(15)DeFeudis FV (2002b) Effects of Ginkgo biloba extract (EGb 761)on gene expression: possible relevance to neurologicaldisorders and age-associated cognitive impairment. Drug DevRes 57:214235

(16)Oberpichler H, Sauer D, Rossberg C, Mennel HD, Krieglstein J(1990) PAF antagonist ginkgolide B reduces postischemicneuronal damage in rat brain hippocampus. J Cereb Blood FlowMetab 10:133135

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ȥ쥹ˤϥ祦ե

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https://www.ncbi.nlm.nih.gov/pubmed/14737017



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https://www.ncbi.nlm.nih.gov/pubmed/11394191


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ADHDβ򥵥ݡȤ [1]


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ܤǤϥץȤǤ뤳οʪķϤνȤäˤΤळȤϡۤ褵Ǥ


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SWITCHޤ COOL SWITCH ɤǤ礦
ADHDɤȤ륤祦եͻ (COOL SWITCH ϥꥫͻ)ۥե륻ϤäƤ뤫Ǥ

Ȥ˥祦եȹͻ(ޤϥꥫͻ)ɤ
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[1] Хѥ˥饨ϡϤȵϡŻ̤ȥ顼̲Ƭˤͭդ˲Ҷγؽϡϡϡȿ塣ǾǤιѡ ADHD ͭѤǤ롣
PMID19944749 http://www.ncbi.nlm.nih.gov/pubmed/19944749

[2] Хѥ˥饨ϲˤ뵭Ͼ㳲
PMID20703343http://www.ncbi.nlm.nih.gov/pubmed/?term=20703343

[3] Хѥ˥饨ϥåȤƬΡϤʤǾιѤͥ¥ʤ
PMID10815010http://www.ncbi.nlm.nih.gov/pubmed/?term=10815010

[4] Хѥ˥饨ϡȥ쥹ˤ̤ͥ˲ץȥͭ뤳Ȥǧ
PMID12957224http://www.ncbi.nlm.nih.gov/pubmed/?term=12957224

[5] Хѥ˥饨ϥåȤγCA3ɼμ͵Ĺ
PMID21892534http://www.ncbi.nlm.nih.gov/pubmed/?term=21892534

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äƹͻϡ륳դˤɤƶ򤪤ܤ褦Ǥ


θʸϡͻˤդޤʬ󥻥Υ Rb1 륳󡦥꡼䤷Ϥ㲼դ𤷤Ƥޤ


зϤΥнˤ륳ߤؤginsenoseidesαƶ
PMID: 1338897Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings.
www.ncbi.nlm.nih.gov/pubmed/?term=1338897


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ΡֶʳפȤϥ˥塼˥륿ߥ󤬲ή˥塼󤬲ư򵯤䤬ƻǤȤݤǤ

˥塼γưХ󥹤򡢹ͻͭʬΩľ褦Ǥ [8.9.10]





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Υޡȥץʤ顢
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[1] Xue JF, Liu ZJ, Hu JF, Chen H, Zhang JT, Chen NH. Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. Brain Res. 2006 Aug 23;1106(1):91-8. Epub 2006 Jul 11.
[2] Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int. 1992 Jul;21(1):1-5.
[3] Sloley BD, Pang PK, Huang BH, Ba F, Li FL, Benishin CG, Greenshaw AJ, Shan JJ. American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. J Psychiatry Neurosci. 1999 Nov;24(5):442-52.
[4] Abe K, Cho SI, Kitagawa I, Nishiyama N, Saito H. Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats. Brain Res. 1994 Jun 27;649(1-2):7-11.
[5] Samira MM, Attia MA, Allam M, Elwan O. Effect of the standardized Ginseng Extract G115 on the metabolism and electrical activity of the rabbit's brain. J Int Med Res. 1985;13(6):342-8.
[6] Himi T, Saito H, Nishiyama N. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chem Pharm Bull (Tokyo). 1989 Feb;37(2):481-4.
[7] Rudakewich M, Ba F, Benishin CG. Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1). Planta Med. 2001 Aug;67(6):533-7.
[8] Kim YC, Kim SR, Markelonis GJ, Oh TH. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res. 1998 Aug 15;53(4):426-32.
[9] Kim S, Ahn K, Oh TH, Nah SY, Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun. 2002 Aug 16;296(2):247-54.
[10] Kim S, Kim T, Ahn K, Park WK, Nah SY, Rhim H. Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochem Biophys Res Commun. 2004 Oct 15;323(2):416-24.

ADHD βԤǤϡ֤Ĥơ

ӥǥ󥹤ϡǤ⤴Ҳ𤤤ޤ


ȥ 祦ե 󥻥󥨥 (ꥫͻͻ)
http://livedoor.blogcms.jp/blog/taddy_/article/edit?id=51782758


ADHD οǴ˳ 3 ~ 17ФޤǤλƸ36ͤоݤȤǡƸˤϡ ꥫͻ 200mg ȥ祦ե 50mg äץ1 2ץ롢ʢ4Ƥ餦


Ϥ2ָ4ָɾԤ


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μ¸ǻȤ줿ʬ̤ϡХѥ 50 ǡ12֤Ǥ


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ꥫͻޤϹͻ祦եХѥ򤪻



ܤΥץȤǤοʪޤޤƤ륵ץȤޤ


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2ץˡ祦ե120mgͻ200mgХѥ80mgۥե륻100mgäƤΤSWITCH

祦ե120mgꥫͻ200mgХѥ80mgۥե륻100mgäƤΤCOOL SWITCH

ꥫͻˤĤƤϡ󥰥꡼򶯲ǽ⤢ޤ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952762/

󥰥꡼ȤϺȵΤȤǡ

Ϥ夭ȯȤΤϡ󥰥꡼򤦤ޤȯ뤳ȡǤ⤢ޤ

ޤꥫͻϡͥ륮ݡȤʤᡢ10塢𡢤Τܤ䤹͡찵οͤˤ礤Ǥ

ͻ礦μꥫͻ礦μϻƤߤʬȤȤ⤢ޤ

ƤϻͤǤ祦եȥۥե륻Ȥ߹碌ϡϤʤɡǾΥѥեޥ󥹤˹׸ǽ⤤Ǥ
http://atman.asia/archives/51897998.html


Ϥۤͤϡ SWITCHCOOL SWITCH ƤƤߤƤϤǤ礦

ޥŷǤ䤵Ƥޤ



[1] Lyon MR, Cline JC, Totosy de Zepetnek J, Shan JJ, Pang P, Benishin C. J Psychiarty
Neurosci. 2001. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. 2001 May;26(3)221-8.

[2] Negi KS, Singh YD, Kushwaha KP, Rastogi CK, Rathi AK, Srivastava JS.
Clinical evaluation of memory enhancing properties of Memory Plus in
children with attention deficit Hyperactivity disorder. Indian J Psychiatry
2000; 42: 42-50.


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