ȿռԤΤ
ץ

ޡȡץȾϤޤӥͥޥ󡢱̿ĩढʤΤ긵ء

2019ǯ03

ꡡ ϤȽϤؤθ̤ԤǤΤϼλĤΤɤǤ礦

祦եݤ롣
ͻݤ롣
祦եȹͻʻݤ롣


祦եϡͻʻݤޤ礦


礦Ϥʥӥǥ󥹤ΤҲ

ȯ䤵ƤGincosanפѤϡϡϤؤμ¸Ǥ

˻Ȥ줿 Gincosan 160mg Ȥϡ1ץΤȡ

祦ե60mg ͻ100mg äƤޤ

󥯤ϡGincosanΥ᡼ȡ
http://www.ginsanaproducts.com/our-products/gincosan.html


Ȥǥ祦դȹͻ

ܤΥץǤϥΥå SWITCH ʤߤ⤷ޤ

SWITCH ϡץ˥祦ե60mgͻ100mgƦ쥷ʪʥۥե륻ͭ50mgХѥ40mg äƤޤ

ˤɤȤ߹碌Ǥ

SWITCH Τϼ¤˹Ǥ
(COOL SWITCH Ф褦Ǥ)

ʤˤܿ

Ȥȥ٥󥭥祦Ƥޤ顣



(祦ե)ȹͻݼ褹뤳Ȥˤ롢ŪṲ̄ɾӥ塼

A systematic review of research investigationing the physiological and psychological effects of combination Ginkgo biloba and Panax ginseng into a single treatment in humans:Implications for research design and analysis

PMID: 30729756
https://www.ncbi.nlm.nih.gov/pubmed/?term=30729756


Abstract
طʤŪͻȥ󥳤ΤѤƤϡ֥ץȤǤ׾Ūӥǥ󥹤ϴˤϲƤޤ

ΣĤΥϡ֤뤳Ȥˤ̤餫ˤȻפޤ


ˡ桹ϿͤоݤȤ2ĤƱݼ褷ŪṲ̄ˤꤽθ̤Ĵʸоݤ˥ӥ塼ȤǤޤȤޤʰʲά


̡8ĤʸĤޤäȤϤäꤷФƤΤϡԤؤν۴Ĵ/ɷϥƥؤͭȡԤȷͤФ󼡵ؤθ̤Ǥ


Introduction
ͻȥ󥳤ϤɤŪʥϡ֥ץȤǤ

줾ñΤ͡ʸ̤Ƥꡢ㤨пͻзϤοãʪФ̤𤵤Ƥꡢޤߥɤͽɤ뤳Ȥ⼨Ƥޤ

󥳤γʪޤзϤοãʪϩФ̤ǧƤꡢзϡзϤήĴ뤳ȤǧƤޤʰʲά


Results
ֺǽ1992ǯǶ2004ǯǤ

٤ƤPanax ginsengʪG115 Ginkgo bilobaʪGK501ѤƤޤ


3.2.1 ˤGincosanȥץ饻ܤȤθ̤
Kiesewetter餬𤷤Ƥꡢܥץ饻ܥȥ򺵻η10ͤ︳Ԥоݤ˹ԤäƤޤ

Gincosan160mgͻ100mg祦ե60mg
or
320mgͻ200mg祦ե120mg
ñ60ʬṲ̄ɾƤޤ

η̰졢ޤ찵̮쾮ĶŽӺٷɤǤַ®٤βǧޤ

θ̤320mg⤤ΤǤ


3.2.2 Gincosanȥץ饻ܤǤĹ/̤
1997ǯKiesewetterGINCOSANοͤιưФ̤ĴƤޤ

43-72Ф85ͤ︳Ԥоݤܥಽץ饻ܥȥ븦ηǹԤäƤޤ

ǽ4֥ץ饻ܤθ8GincosanƤ餤4ܻ8ܻǤ׾ɾԤäƤ롣

ʸǤϡ4ܡס8ܡפȤΤGincosanϤƤ4ס8פʤΤ󥳥٤ƤλƤ4ס8פʤΤ񤫤ƤʤᡢˡĹ̡פȸڤ뤳ȤϤǤʤ

Τ褦Ϥ뤬GincosanϿͤιưѲ⤿餷褦Ǥ

ä8ܤɾǽϤ˺äݤDzǧƤޤ


3.2.3 Gincosan̤ˤ/Ĺ̤˽֤
1997ǯWesnesʿǯ54Ф64ͤ︳Ԥоݤ80mg, 160mg, 320mg3Ĥ̤򤽤첶Ƥ餦ԤäƤޤ

2ĤǧιܡʵϤϡˤФɾ︡ԤεʬФɾӾԡ(Vienna Determination Test)ȱư翴ɾԤäƤޤ

ɾ1ܡ30ܡ90ܤǹԤޤ

160mg320mgǤϵϤβǧ줿80mgǤͭǧޤǤ

ȿФ80mgǤϺٻξ徺ޤ졢︳ԤοΤФƤͭפʸ̤ǧޤ

ԡɤǤͭդѲǧޤǤʰʲά


3.2.4 ĹĹ/ˤ̤ˤGincosanθ
Ϣ4Ĥθ椬ʤƤޤ

Wesnes2000ǯ256ͤηͤоݤ160mg 12󡢤⤷320mg 11Ƥ餤ܥץ饻ܥȥ븦ԤäƤޤ

ΥץȥϤʤꤷäꤷΤ16ˤ錄äƹԤƤޤ

٤Ƥ︳Ԥ2֥ץ饻ܤƤ餤θ12Gincosan򡢤2֤wash-out֤ߤƤޤ

ɾϥץ饻塢Gincosanϸ4812λ2ܤǹԤƤޤ

1) Τ2) ᤵ3) ϡ4) Ϥλ³ɾܤȤƤޤ

̣̤ȤơGincosan4,8,12,14ɾ٤ƤǵϤͭդʲǧƤޤ

Ĥޤꡢθ̤߸2ֻ³ΤǤ

ΤȤˤꡢGincosanϵϤĹṲ̄뤳ȤΤ줿ΤǤʰʲά


3.2.5 Gincosanȥץ饻ܤθ̤
ṳ̂ˤĤƤϡKennedy餬2001ǯܥץ饻ܥȥηǸԤäƤޤ

ʿǯ20.6Ф20ͤηͤоݤ7֤wash-out֤ߤΤ320mg, 640mg, 960mgƤäƤޤ

ơ1,2.5,4,6ֻǤɾԤޤ

6a) μb) 󼡵c) 󥰥꡼d) ԡɡe) Ϥᤵf) ϤΤ ˤĤɾƤޤ

960mgǤϡ1֤6ֻǤεϤμβǧޤ

θǤϵϤФͭפʸ̤ǧ졢Ϥؤθ̤ǧޤǤ


3.2.6 Gincosan󥳡ͻץ饻ܴ֤Ǥṳ̂
Kennedy2ܤθGincosanȤιʪñΡʥ󥳡ͻˤǤθ̤ӤԤäƤޤ

ʿǯ21Фη20ͤоݤ7֤wash-out֤ߤΤ˥360mgͻ400mgGincosan960mץ饻ܤƤ餤ޤ

1,2.5,4,6֤λ3.2.5θɾ6ܤˤĤĴޤ

6ܤɾ̤򸫤ȡGincosan960mg6ץǤϡȵμɤβǧޤ

äơθ̤2Ӥξ徺ˤ⤿ΤǤ뤳Ȥ狼äΤǤά

θGincosanȤιʪñΤȤӤ򤷤Ȥǡ̤ˤĤɾ뤳ȤǤޤ

μ˴ؤƤϡ󥳡ͻñΤǤäƤ⵭μβϸΤΡ̤ȯ֤Ϥ줾ۤʤäƤޤʥ󥳤6֡ͻ4֡

η̤ˤꡢ󥳤ȹͻȤ߹碌뤳ȤˤꡢμβѥեˤϤäȤΤˤʤǽꡢ˸ȯ֤ᤤΤˤʤ60ʬ˲ǽޤ


3.2.7 ṵ̂¸̤ˤGincosan󥳡ͻץ饻ܤ
ScoleyKennedy3ܤθǤ3.2.6θ򤵤˿ʤᡢ̤ˤ̤ΰ㤤餫ˤ뤿ᡢ3Ĥθ椬ԤƤޤ

ܥץ饻ܥȥ򺵻ǥ󥳤120mg240mg360mgͻ200mg400mg600mg󥳥320mg640mg960mgƤäƤޤ

̥󥳥ǤΤ̰¸θ̤ǧޤʰʲά


3.2.8 ά


Discussion
󽸤᤿8Ĥθ̤θƤˤͻȥ󥳤ΰ߹碌ǧεǽβˤ̤뤳ȤϤäȤޤ

θ̤ϷͤǤǧ졢60ʬ٤Ǹ̤ȯ߸14ٻ³뤳Ȥ狼ޤʰʲά
gincosan

switch %282%29

Amazon
https://www.amazon.co.jp/
ŷ
https://www.rakuten.co.jp/

򹯤ʼǯ︳ԤоݤȤ󥳤ûݤǧεǽФ̰¸̤θƤ

The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers.

PMID:11026748
https://www.ncbi.nlm.nih.gov/pubmed/?term=11026748


Abstract
Rationale:祦եʥ󥳡ˤĹ뤳Ȥˤꡢǧεǽ뤳Ȥ狼äƤƤޤ

󥳤ûŪѤˤĤƤϤϤäȤ狼äƤ뤳ȤϾʤ֤Ǥ

ǶθˤꡢCR(Cognitive Drug Research)ˤ¬ꤵ줿4Ĥǧι(Ϥ®١ϤΤ®١Τ)ǧεǽѲ¬ꤹΤͭѤǤ뤳Ȥ狼äƤޤ


Objective:θǤϥ󥳤CDR4ܤΤʸ̤⤿餹ɤɾޤ


Method:θܥץ饻ܥȥ򺵻ηǹԤޤ

20ͤ︳Ԥоݤ˥ʪ120mg,240mg,360mg⤷ϥץ饻ܤƤ餤ޤ

ǧεǽCDRԥ塼ƥȤˤ1,2.5,4,6֤¬ꤷˤǧεǽ4ܤˤĤɾޤ


Results:ץ饻ܷӤƥ󥳤¿ͭդѲǧޤ

ǺǤϤäȤΤ̰¸Ϥ®٤βǤ

240mg,360mgɤͭդʲǧ졢2.5ָǺǤϤäꤷ̤ꡢ6ָǤ⤽θ̤ϻ³Ƥޤ


Conclusion:θǷ򹯤ʼ㤤︳ԤоݤȤǥˤϤλ³Ūʲǧޤ


ʾѤλ

Υ祦եϡ

Υå SWITCHCOOL SWITCH

2ץ˥祦ե120ӡ

äơǾǽΤιͻCOOL SWITCH ϥꥫͻˡХѡۥե륻۹礵Ƥޤ

Ȥ߹碌ˤϡɹƯԤǤޤ

ϤȵϤɤΤǤϤʤǤ礦

ޥ
https://www.amazon.co.jp/
ŷ
https://www.rakuten.co.jp/

ư㤤ͤˤ롢ǽؤE-OJ-01ʪʥ른 ˤθ

Effect of E-OJ-01 on cardiac Conditioning in Young Exercising Adults:A Randomised Controlled trial.

PMID:27930383
https://www.ncbi.nlm.nih.gov/pubmed/?term=27930383


Abstract
طʤŪ¡η򹯤ϱưѥեޥ󥹤˱ƶͿޤΥǡߤȡ翴äϻϤä⤿餷ޤ

ߥʥꥢ른ʡTAˤϿɤη򹯤ͭ͡פʱƶ뤳ȤʬäƤޤ

θϷ򹯤ʼǯˤTAʪE-OJ-01ˤο¡ξ֤򼨤ޡؤθ̤򸦵椹뤳ȤǤ


ǥ󡧥ಽܻηǹԤǯαưԤäƤ˥ץȤȤE-OJ-01Ƥäǡ̤Ȱɾޤ

32ͤη򹯤(18-40)ǻưԤäƤҤȤоݤ56400mgE-OJ-01⤷ϥץ饻ܤƤ餤ޤ

LVEF(Ψ)orMPImyocardial performance indexʢǽ㲼ĥǽ㲼ΤɤǤMPIͤ礹ˡˤơBorg RPE(Ūư(ưμŪô٤ͤɽΡ

ͤ㤤ۤɳڡ⤤ۤɤĤưȤʤ))򸦵泫28ܡ56ܤɾޤ

ˡ56ܤCK-MBӥȥݥ˥TͤˤĤƤɾԤޤ


̡ץ饻ܷӤ56ܤλE-OJ-01ǤLVEFͭդʲǧ(P=0.0001)ޤMPIͭդ㲼ǧޤ(P=0.001)

BorgǤȤ館뱿ưϫ٤Ǥϥץ饻ܷӤE-OJ-01Ǥϸǧޤ

CK-MBӥȥݥ˥TͤˤͭդѲǧޤǤ

TA(E-OJ-01)Ϸ򹯤ʼǯˤƿǽΨ򤢤¡ξ֤뤳Ȥ狼ޤ


ʾ塢Ѥλ

른ʤϥɤؤο¡ΤѤޤ

ƯϲʳŪʼ¸ˤɽƤ褦Ǥ

ɡԥ󥰸륢꡼ȤϡդʤФʤޤ

ܤǤϤޤΤƤʤ른ʤϥץȤȤƼ뤳ȤǤޤ

ܤǤϥΥȡ TORCH˥른ʤ۹礵Ƥޤ

ޥ
https://www.amazon.co.jp/
ŷ
https://www.rakuten.co.jp/

ʡʵ㲼򼫳Ф뤳ȡˤΤǯܿͤεϤФƦۥե륻θ

Soybean-Drived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

PMID: 21103034

ʢѤϡˤơ
https://www.ncbi.nlm.nih.gov/pubmed/?term=21103034


Abstact
Ʀۥե륻Ʀ쥷󤫤ۥե륻ǤʤΤǯܿͤǧεǽФƦۥե륻θ̤餫ˤ뤿ܻԤޤ

䵭Ϥ԰¤Τ78ͤǯ(5069)˥˷᤿Ʀͳۥե륻(100mg,300mg/)⤷ϥץ饻ܤ6Ƥ餤ޤ

̤ȤƦͳۥե륻ȤǷոͤ찵̮ʤɤѲϤʤѤǧޤǤ

λǥ㤫ä︡Ԥǥۥե륻Ȥˤ뵭Ϥͭդʲǧޤǥץ饻ܷǤѲޤǤ


Introduction
ۥե륻Ǿ¿¸ߤƤιʪǤ

ۥե륻зϤؤαƶΤƤޤ1-5

ꥫ䲤Ǥ׾ǵͳۥե륻ǯ︳ԡ6-10Ϥ䥢ĥϥޡ¤δԡ8,9ϡǯˤ뵭㳲(AAMI)δԡ10ϤǤǧεǽβ뤳Ȥ狼äƤޤ

ͳۥե륻BSEʶ¡ˤΥꥹ뤿ᡢߤǤϻѤƤޤ

Ʀͳۥե륻BSEΥꥹʤᤵ˸椬ԤƤޤ12


ʰʲ1995ǯGindin餬AAMIΤǯ︳ԤФƦͳۥե륻(300mg/ 3)εϲ̤𤷤ΤǽǤ17

CrookƦͳۥե륻(300mg/12)AAMI︳Ԥǵϲǧ줿𤷤Ƥޤ18

¾Ʊͤ𤬤ޤܿͤоݤȤΤϤޤǤ

桹2005ǯAAMIǯ︳ԤФƦͳۥե륻Ƥ餤DWR(delayed 3words recall)ƥȤͭդʲǧޤ21

θ١ȤƲ桹ϵ԰¤Τܿǯ︳ԤоݤƦͳۥե륻(100mg⤷300mg/6)θ̤ܻηǷײ褷ޤ

Ϥˤ԰¤Τ︡ԤФ뤿RBMT(Сߡɹư)Ѥޤ22

ϵϤɾ˥եƤǤ

6֤ΤΤ3Υեå״֤ȤꡢߤΤƦۥե륻θ̤뤫ɤĴ٤ޤ


ˡ
оݡʰ
50-69Ф߽˽Ǥ䵭Ϥ԰¤ΤоݤȤޤ

ޤ︳ԤεϤ㲼٤ɾäHDS-RDWRιܤˤĤĴޤ

RBMTHDS-RMMSEʤɤѤ꡼˥󥰤Ԥޤ

η̡700ͤΥܥƥΤ78ͤޤ

5ͤɥåץȤ̤Ȥ78ͤȤʤޤ


ǥ
θϥಽܻηǹԤ︳Ԥ3Ĥηʬޤʤ줾28ͤġˤɤηǤʿǯ̡ǯҤΥʤɤǰ㤤ϤޤǤ(ɽ1,5)

꡼˥󥰤ԤäƣˣĤη˥ץ饻ܡۥե륻100mg/ۥե륻300mg/򣶥Ƥ餤ޤ

θ夵ˣвѻԤޤ

飶ܡвѻ壳ܤɾԤޤ

ǧεǽɾŪHDS-RMMSEޤĵʬɾGDS򡢤ưɾ뤿˷ոǢԤޤ

ˡRBMTEMCˤĤƤвѻɾԤޤ

RBMTˤĤ
RBMTϵϤˤĤƸڤƥȤǤ22

12ܤʤꡢĿͤνͤ̾ʹˬ줿ȤäεˤĤɾޤʰʲά

HDS-RĹëˤˤĤ
HDS-RǧξɤοǤܤǤ褯ѤƤɾˡǤ
3021ͤ㤤ǧξɤβǽޤ

桹ϤΤDWRιܤܤޤ

ȤΤϡͽƦۥե륻Ϥιܤ˺Ǥ̤äΤǤ21

DWRȤΤϡ︳Ԥ3ĤδϢΤʤñ󼨤ȤǤäƤ餦ȤˡǤ

EMCﵭåƥȡˤˤĤ
EMCϵ㳲ˤǤξ㳲ΤƤɤɾˡǤ28ǵ䤹˴ؤپ13ܤɾޤ



ոǢۥե륻λľ(6)λ3ǹԤޤ찵̮ȤäХ륵ˤĤƤɾޤ




֤̤ơۥե륻ץ饻ܤȤ˴ϢѤϳǧޤǤ

ɽ2,3˼褦ˤ٤ƤηǷ컻ӷͤǤͭդѲϳǧޤǤ
Х륵ǢǤѲϤޤǤ(ɽ4)


ǧεǽ
RBMTǤΥѲɽ5˵ܤޤ

3٤Ƥǥͭդʾ徺ʲˤǧ졢λǤƦۥե륻ȥץ饻ܷȤδ֤ˤͭդʰ㤤ǧޤǤ

RBMT19ʾäRBMT19ʲäˤƤͭդʺǧޤǤ

HDS-RˤĤƤ3٤ƤǾ徺ʲˤǧ졢3֤ǤͭդʺǧޤǤ

3ηвѻ֤ΤΤץ饻ܷΥοޤƤޤۥե륻100mg/300mg/ɤˤƤ⤤ݻƤΤǤ

HDS-R⥹ǤHDS-Rͭդʰ㤤ǧޤǤHDS-R١λ㤤ǤƦۥե륻ͭդʥβǧ줿ΤǤ

3(A)HDS-RDWRܤ㤫äΤΤǤ

Ʀۥե륻Υ٤ͭդ˲3ηвѻɾƦۥե륻100mg/300mg/ɤˤƤץ饻ܷȤͭդʰ㤤ǧޤ

DWRˤ륹βηϡΥȡ륹βȹƤޤ

ΤȤϡȡ륹βϼDWRܤβˤäƤ⤿餵ȤȤ򼨤Ƥޤ

¡HDS-RΤ¾ιܤǤͭդѲǧޤǤ

ǤѲϾΤǤϤޤMMSEǤDWRܤˤĤƤƱͤηǧޤ

Ʀۥե륻Ǥ٤ƥͭդʲǧޤβ٤ϥץ饻ܷӤͭդʰ㤤ФۤɤΤΤǤϤޤǤ


ʰȴ
դλפФ٤ǧξɤʳǤɾͭѤǤȸƤ30,31Ϻθ̤ǤƦۥե륻ǧξɤΤμŤȤͭǤȻ򼨤Ƥޤ

RBMTˤĤƤϡǧΤ̾ȤδϢդʤɤιܤۥե륻ˤäƥȤ𤬤ޤ18,19

󡢤Τ褦ʲʤäĤװȤơ︳Ԥ餹Ǥ˹⥹ޡƤͤǤꡢʾβʤäǽޤ

桹Ϻ󡢷ۥե륻ͤ¬ϹԤޤǤĤʪư֤θۥե륻®䤫˵ۼ졢BBB(Ǿ)̲ᤷǾã뤳ȤǧƤޤ32

åȤѤƦۥե륻ǾɤľͿ븦Ǥ⵭ϤβǧƤ15ϡƦۥե륻Ǿľܸǽޤʰʲά

ʾѽλ

ơҤȯ䤵Ƥ륹å SWITCHޤ COOL SWITCHϡ
ǯ 50аʾˤΡʪ˺פФɤȤ뤫⤷ޤ

ʬƦ쥷ʪʥۥե륻ͭ100mgͭƤޤ

¾ˤ⡢Ǿη򹯤˴Ϳɤϡ֤ġ

祦աͻ(COOL SWITCH ϥꥫͻ)ХѤޤޤƤ뤫Ǥ

Amazon
SWITCH
switch %282%29

COOL SWITCH


ǯĶǾˤƥStARD3δط

Rerationship between Concentrations of Lutein and StARD3 among Pediatric and Geriatric Himan Brain tissue

PMID: 27205891

Ѥɽϥˤ
https://www.ncbi.nlm.nih.gov/pubmed/?term=27205891

Abstract
ƥϥΥɤǤꡢʹ֤ǾŪ¸ߤƤޤ

¿θˤƥǧεǽδ֤ˤϴϢ뤳ȤƤϤޤƥǾȿؤμߤ䤽οпĹؤαƶǧεǽؤʬҳŪ٥ǤɾϤޤʤΤǤ

θŪ3Ĥǯء1-4ǯ55-86СĶ98-105СˤǾƥStARD3ȿˤƷȤ狼äƤޤˤȤδط餫ˤ뤳ȤǤ

Ǿƥǻ٤StARD3ǻ٤ˤĤƲϤԤޤ

η̡ǾǶشطǧ줿ΤǤ

ˤꡢƥϿпĹ˴ͿƤȤȤ狼ޤ

ǯǤϤδطͭդǤ夯ʤꡢ100ǤϴطͭդʤΤǤϤʤʤäƤޤ

100︡10ͤΤ7ͤǧξɤMCIξɾǧޤ

θǡˤStARD3θ䵡ǽ뤳Ȥޤ

StARD3ϿпĹΰ۾βθȹͤƤ륳쥹ƥ͢˴ϢƤꡢƥˤϤμФοݸǽǽޤ


Introduction
ΥɤϿʪ˰Ū˴ޤޤƤ뿧ǤǤ

40ΥΥɤʪ鸫ĤäƤޤ2ΥΥɡ륤ƥȥΤߤ̲᤹뤳ȤǤޤ

Ǥ3쥫ΥɷƱꤵƤꡢΤΤҤȤĤsteroidogenic acute regulatory domain 3(StARD3)ǤStARD3쥿ѥȤɬԲķʤΤǤꡢɥ꥽˦ﴱ¸ߤƤޤ

ƻ͢˴ؤäƤȹͤƤޤ

ǾǤΥ쥹ƥ͢ΰ۾ǯŤͤˤĤ٤Ƥ뤳ȤͤStARD3ǧεǽ˽פʴؤ꤬ǽꡢޤĥϥޡʤɤοΥ󥻥åȤˤʤäƤǽޤ

ΤᡢθǤǯ100ǾǤΥƥStARD3δϢɾ뤳ȤȤޤ


Materials and Methods(ȴ)
оݡ(1-4)ǯ(55-86)100(98-105)ǾȿĴԤޤ

Ǿȿˤ̤͡ޤޤƤꡢ(Hipp)¦Ƭ(TC)Ƭ(FC)Ƭ(OC)ޤ


Results
︡Ԥħɽʾά

Ǿƥǻ
Ǿƥǻ3ǤǾȿΥȥ󥹥ƥʿǻ٤ɽ2˵ܤƤޤ

٤ƤǾȿǥȥ-ƥ󤬸Фޤ

-ƥ175ͤΤߡǯǤ167ͤΤߡ100Ǥ154ͤΤߤǸФޤ

ƬդȳϤȤδ֡100Ƭդ¦ƬդȤδ֤ǤΥȥ-ƥǻ٤˺ϤޤǤ

ǯθƬեȥ-ƥǻ٤ϳϤΤ̤ͥ˹⤤Ȥ̤Ǥޤ(P<0.05)

ޤ100Ǿ٤ƤΥƥǻ٤ʿѤ椷ͭդ˹⤤Ȥ̤ˤʤޤ(P<0.05)


ǾStARD3٥
ǾȿStARD3ѥΥ٥ϥ֥åˡˤХɤǻ¬Ԥޤ(ɽ2)

Ƭդȳϴ֡ǯƬդ¦Ƭմ֤StARD3ХɤǻͭդʺϤޤǤ

ܤ٤ϥ-ƥ򸡽ФǤʤäǾȿӤƥ-ƥ򸡽ФǤǾȿǤͭդStARD3٥뤬⤫äΤǤ(P<0.05)Τ褦ʺǯ100ǤǧޤǤ


Ǿƥǻ٤StARD3٥δϢ
줾ηǾƥǻ٤StARD3٥δϢʬϤޤ

ǾΥȥ-ƥǻ٤StARD3Хɤǻͭդشطˤޤ(P<0.001)(1A)

Ǿγ̤ǸƬդǤͭդشطȤʤޤϤǤشطǧޤǤ

Ϥ̤ΥץʤäȤȹͤޤ

-ƥ⤹٤ƤǾȿStARD3Ȥͭդشطǧޤ(1BP<0.05)

ǯǤǾȥ-ƥǻ٤StARD3٥Ȥδ֤ˤϤ鷺شطǧޤ(P=0.053)(2A)

StARD3ȥ-ƥǻñȤStARD3ƥǻ٤δ֤ˤͭդشطǧޤ(2B,C)(ȤP<0.05)

ƬդӳñȤǤͭդʴϢǤޤǤϥץȹͤޤ

˥ĥϥޡ¤δԤƲϤԤäƤ⡢ƥǻ٤StARD3٥Ȥδ֤ˤṲ̄ͥĤޤ

100ǤStARD3ȥȥ-ƥ󡢥-ƥƥȤδ֤˴ϢǧޤǤ(3A-3C)


Discussionʰȴ
η̤ǥƥStARD3Ȥδ֤ͭդʴϢ뤳ȤͤȡǾȿؤΥƥŪѤϤη祿ѥˤΤȹͤޤ

شط˶ǯǤ夤Τˡ100ǤϴطʤʤäƤޤʰά

Ǿ˥ƥŪ˽Ѥ뤳Ȥʻζشطˤƥ󤬼ǯοпĹ˽פ̤Ƥǽޤ

ǯˤƥStARD3δϢθϡˤStARD3θ⤷ϵǽȿǤƤǽޤ

θǤ⡢ƥStARD3δϢɾݤ˥ĥϥޡ¤򴵤äƤ︳ԤƲϤԤȡƥǻ٤StARD3٥شطϤϤäȤΤˤʤޤά


θǥƥ󤬿ͤǾ˦Ū˼ޤ뤳Ȥ狼ޤ

StARD3ƥŪ礹뤳ȤͤȡǾ˥ƥŪ˽Ѥ뤳ȤĤ⤷ޤ

StARD3ϢѥǤꡢƥǸĤäƤ19ϤȤθȡƥϥ˥塼֤Υåס󥯥˱ƶͿ륷ʥץμפʹʪǤꡢĴǽͭʪǤǽޤʰʲά

ѽλ

ƥϡǾץȰ֤Ť뤳ȤǤǤ

ǤϡƥѤƤ륹ޡȡץϤΤǤ礦

ƥ򤽤ŪѤƤΤϡΥ饤 SKYLIGHT 餤⤷ޤ

饤ȤˤϡƥΤۤˤǾη򹯥ݡȤԤǤ륯륯ߥ󡢥顢ԥʡեݻʤɤBBB̲᤹ǤޤޤƤˤ۹礵Ƥޤ

ƥܤη򹯤˴Ϳ뤳ȤϤΤȻפޤ

ȿռԤˤȤäơʥޥۤѥĹָ虜ޤ󤫤ˡܤǾη򹯤򥵥ݡȤSKYLIGHTϡ륢ƥȤʤ뤳ȤǤ礦

CK005

https://www.amazon.co.jp/


ϤäȼѤơ䤨ǺؤΤ⡣

ȿŪ䤨ڤäƤޤˡ

ܿͽоݤˤ˥ӥǥ󥹡



˽ϪκݤΡ(Emblica officinalis Gaertn.)ʪݼ褹뤳Ȥˤɽ̲βȷήβݥಽܻ

Effect of Amla(Emblica officinalis Gaertn.) Etract Ingestion on recovery Body Temperature and Blood Flow Following Cold Stress.

Abstract
Ūθϡ䤨ҴʽоݤȤ˽Ϫɽ̲ȷήβ٤ɾ뤳ȤǤ

ˡ32ͤΥܥƥоݤ˥ಽܻηǹԤޤоݤˡޤॵץȤ⤷ϥץ饻ܤƤ餤ޤ2֤Ǥ˽Ϫɽ̲ȷήβˤĤɾޤ

̡ʪǤɽ̲ȷήͭդʺǧޤ

ͭץȤˤϴ˽Ϫɽ̲ȷήβ¥ʤޤη̤ϥʪ䤨פ򴶤ƤͤˤͭפʥץȤǤǽ򼨤Ƥޤ


Introduction
ܽ1/3䤨򴶤ƤȸƤޤΤۤ䤨פ򴶤礬⤯ǯ𤬾夬ˤĤäޤʰά

Amla(Emblica officinalis Gaertn.)ϲɴǯˤϤäƽפڤȤΤƤޤǮ䥤ɤ֥ޤΰǮǤϰŪڤǤ˭٤ʥӥߥC˥gallic acidellagic acidȤäݥեΡ롢륻ȤäեܥΥɷϤޤǤޤŪŤǡϲΡ䲫աʤɤФƻȤޤʰά

ϹʪȤƤ¦̤äƤޤ13in vitroǥϲƥҥɥ饸⤷ϥѡɥ饸Υ٥󥸥㡼ȤƯǽƤޤ14,15


о
20-40Фη򹯤ܿͽ85ͤȤޤ

Table2˳ʥե䤹Ǥ˥Ƥ硢ǽʤɤǺθˤŬȻפ줿硢θǥ륮ФǽʤɡˤϽޤ85桢32ͤоݤȤʤޤ٤αưåȡῩ򤱤褦ˤꤤޤ륳롢䥨ʥɥ󥯤ʤɤݼ褷ʤ褦ˤꤤޤҡ䥭礦¬ޤǤ1,2ϵƤޤ


Ĵ٤ץ
2ץƤ餤ޤ1ĤΥץ˥ʪ200mg˥ǥȥ7mgˡƥ륷2mgˡǡ1mgˤޤޤƤޤץ饻ܷΥץˤϥǥȥ207mgˡƥ륷2mgˡǡ1mgˤޤޤƤޤ


ά


¬ˡ
︡Ԥ25٤μǰŤˤƤ餤ץȤ⤷ϥץ饻420mg200mlοƤ餤ޤ90ʬ塢μ153ʬξ򤵤餷Ƥ餤ޤ餷ľ塢5ʬ塢10ʬɽ̲Ʒή¬ꤷޤ

ʲά


̡
32ͤ︡ԤXYȤʬޤæԤʤɤX17͡Y14ͤӤޤ򺹻ηȤ뤿ᡢ1ԥꥪɤǤX˥Y˥ץ饻ܤƤ餤1֤Υ󥿡Х֤ΤX˥ץ饻ܤY˥Ƥ餤ޤ

Table331ͤ︡ԤΥǡǤǯνš̴찵ĥ찵̮ɽ̲ήʤɡξǺǧޤǤ


裱ԥꥪɽλ
Fig.2ϴ˽Ϫɽ̲β򼨤ΤǤ˽Ϫ塢μؤɽ̲ץ饻ܷᤤȤ狼ޤ5ʬ¬ǥ2.370.09ץ饻ܷ2.000.17ξ徺ǧ졢ξ徺κͭդʤΤȤʤޤؤηή˴ؤƤϡǤ5ʬλ12.330.69Ȥʤꡢץ饻ܷ10.070.59Ӥͭդ˹⤤ΤȤʤޤ

2ԥꥪɽληή̤餫˰㤦ΤȤʤäᡢ򺹻η̤ɾǤΤǤϤʤȷդޤ
ѤϳǧޤǤ


Discussion
˥ϥӥߥC䥬å顼åʤɤȤäʪޤǤޤɽ䤹Ȥˤηɼ̤ϥɥʥΥ륢ɥʥᥫ˥ˤäƤΤǤ

ơ˽Ϫ10ʬ̤ˤǤϤηɼ̤ΤNEʥΥ륨ԥͥե󡩡ˤ浯ȸƤޤȿϹʪˤäƴˤ䤫Ȥʤ뤳Ȥ狼äƤޤ϶ϤʹѤͭƤꡢκѤˤäɽ̲βήäƤΤ⤷ޤ

¾Υᥫ˥βǽȤNOƯޤNONOSNO󥿡ˤˤäƳɽηɼ̤˴Ϳ油ξ徺⤿餹ȤʬäƤޤNOSϥݥեΡˤäƳޤäơݥեΡϷή䤨ξɾ¤ǽޤ

ʰάKarazawaϡߥʷ쾮ĶŽѤȷʿд˺ѤΤˤ她ȥ쥹ˤ油β᤿Ȥ𤷤Ƥޤ35Ϥη̤ˤ쾮ĶŽѤ油ˤϴϢ뤳Ȥ狼ޤ

桹θǤϥcorilagin䤽¾ellagitannin componentsin vitroǥȥӥˤ쾮ĶŽˤAPTTPT֤Ĺ뤳Ȥ狼äƤޤ36

ĤޤꡢˤϹѤȤȤǤellagitanninκѤˤꥢˤϴ˽Ϫɽ̲βѤȹͤޤʰʲά



ʾ塢Ѥλ

ܤΥץǡ餬äΤϤۤ¿ޤ

Ǥ⤪ǤΤ

Υȡ TORCHǤϤʤǤ礦

ݥեΡ40ʾɸಽ줿 ۹礵Ƥޤ


ޤΥȡˤϡΤۤ¡η򹯤ɤ른ʡ
ȥ쥹ɾΤۡ꡼Х롢ޡȥϡ֤Υĥ۹礵Ƥޤ

ҡʤȿŪǮɤ餻Ʋ

TORCHϥޥǤޤ
ޥ
https://www.amazon.co.jp/

ȥ쥹̤Υޥ͡ȤˤۡХ/ ȥ륷(OciBest)θ̡ܻ

Efficacy of an Extract of Ocimum tenuiflorum(OciBest) in the Management of General stress:A Double-blind,Placebo-Controlled study.
PMID: 21977056
https://www.ncbi.nlm.nih.gov/pubmed/?term=21977056


Abstract
ȥ쥹̤ΥȥˤOciBestʥۡ꡼Хʪˤθ̤餫ˤ뤿˥ಽܻԤޤ

6֤ˤ錄äơ79ͤФƥץ饻ܤ71ͤФOciBestͿޤȥ쥹˴Ϣɾٹ礤a symptom rating scaleѤ2,4,6ܤɾƤ餤ޤ6ָ塢˺äݤ˴ؤꡢΥȴ١̲㳲٤ȤäɾOciBestͿͭդ˸ޤP<0.05

ˡΤξɾץ饻ܷӤƸƤޤ

OciBestͿǤϥץ饻ܷӤ1.6ܤ⤷39ʾͭդʲǧ줿ΤǤ

θ桢ͿˤѤǧޤǤθOciBestϸŪǤ뤳ȤʬäΤǤ


ʸʰʸϾ嵭󥯤򻲾ȡ
Introduction
ȥ쥹ˤĤơʾά

Ocimum tenuiflorum Linn.Tulsi⤷ϥۡ꡼ХȤΤƤꡢʤ°Ƥޤ١ǤO.tenuiflorumϥץȥ/ȥ쥹̤ȸƤޤ14͡ʸ̤ǧƤޤ15-20

O.sanctumǾΥƥ륢ߥ󡦥Υߥ󥪥㲼ͽɤɥѥߥ5-ҥɥȥץ䤹ȤǧƤ롣21

Bahattacharyya԰¾㳲δԤФ2O.Sanctum500mg/ץ롢2/ˤͿO.Sanctumθ̤Ƥޤ22

ˡ
оݼԡƱդ18Ф65ФηͤTable1ƬˡŻưة̸ʤɡˤ14ιܤΤʤȤ3ܤƤϤޤͤоݤȤޤ

μռǾ륮äƤͤϽޤಽܻηǸԤޤ

ץ饻ܷOciBestͿȤʬī1ץ롢ͼ2ץ1200mgˤƤ餤ޤ2,4,6Table1ξɾ뤫ɤĴޤ


̡
158ͤоݤȤʤޤ
ץ饻82͡45͡37͡ˡOciBestͿ76͡44͡32͡2δ֤˽ǯνš̮찵ʤɤǺϤޤǤ

2ξɾˤĤƤޤȤ᤿ΤTable3Ǥ
Ϳ٤ƤΥˤξ֤ͭդʺǧޤǤ

ɤηˤƤʿѥϸ򼨤ޤץ饻ܷǤϤĤιܡʡֿƤͤ򤱤ˡ«˺ˡˤǾɾ³ƤǤʤʤ̸פγа۾סֿ̲㳲١פȤäܤǤϰ⤢ޤ

ͿȡͿ2,4,6Ӥ硢OciBestͿǤϡ˴ؤװʳΤ٤Ƥιܤʿѥͭդʸǧޤ

ץ饻ܷǤϡְ۾İСʼĤʤɡˡס˴ؤסγа۾סֿƤͤ򤱤ס«˺פȤäܤǤǤͭդʺǧޤǤƬˡסְŻưסְIJɾ١ס֥Υȴ١סֿ̲㳲١פȤäĤιܤDzǧޤ

ޤͿͿ4,6Ӥǡ̸פ˺äݤס֥饤餷١פȤäɾDzǧޤͿͿ6Ӥǡ֤ĤȤϰ㤦١ʴ𡩡ˡפιܤDzǧޤ

OciBestͿǤϡͿ2ܤͿ4,6ܤǤӤǡƬˡסְŻưסְIJɾ١סֿ̲㳲١פιܤͭդʸǧޤ

ޤͿ2ܤͿ6ܤӤǡ˺äݤפ˴ؤס֥饤餷١ס֥Υȴ١פʿѥͭդʸǧޤ

ץ饻ܷǤϡͿ2ܤͿ4,6ܤӤȤĤιܡʡְIJɾ١פ֥Υȴ١סֿ̲㳲١סˤͭդʺǧޤǤ

Ϳ4ܤͿ6ܤӤǡOciBestͿǤϡ˺äݤפ˴ؤס֥饤餷١ס֥Υȴ١סֿ̲㳲١פιܤͭդʸǧޤ

ץ饻ܷǤϡ֥饤餷١װʳΤ٤ƤιܤͭդʺϽФޤǤ

ξӤȡͿ2,4Ǥθ̤ξƱäͿ6ܤǤϡ˺äݤפ˴ؤס֥Υȴ١סֿ̲㳲١פιܤOciBestͿͭդʲǧޤ

潪λξӤȡOciBestͿץ饻ܷ٤ơɾͭդʸǧޤ

ץ饻ܤӤOciBestθ̤٤ƤΥȥ쥹ܤǧ줿ΤǤOciBestθ̤ϥץ饻ܷӤ39%(1.6)⤤Ȥ̤Фޤ

ɤηˤƤͭݤϳǧޤǤ


ʾ塢Ѥλ

ۡ꡼Хϥץȥʬवޤ

ΥץȥѤ뤫

¿Υץȥ֥ɤѤ뤫

ĤϸϤۤʤޤ

Ԥϡȥ쥹й褦Ư

Ԥϡȥ쥹˽褦Ư롢Ȥ褦ʰ㤤Ǥ

ȥ쥹ĶؤŬԤʤ顢
ץȥϡʣ֥ɤѤۤɤǤ礦

ȥ쥹 ޥͥȤˤơ
Υ󥻥 CONCENT ϡɾΤ륹ޡȥץΤҤȤĤ⤷ޤ

ץȥȤơ
ۡ꡼Х롢쥦ƥʥ٥ꥢͻˡǥ ۹礵Ƥ뤫Ǥ

ޤä۹礵Ƥӥ󥫥ޥʡϡ
ϤȵϤؤΥݡȤˤʤ褦Ǥ

Ѥ񤤥ȥ쥹ۤϡ
Υ󥻥 CONCENTƤƤߤƤϤǤ礦
ޥŷǽǤ
ޥ
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ΥڡΥȥåץ