ĥ (C.asiatica) ϡȥ륳ء ɤΥ١ѤƤǤ롣



̾ Asiatic pennywort

Indian Pennywort

Indian water navelwort

wild violet

tiger herb ȤƤФƤ롣


Ilkay Erdogan Orhan 𤷤ӥ塼Ȥˡθ̤ˤĤƽҤ٤롣


ĥȤƤϡȥƥڥ󥵥ݥΥɤפʹʪǤ롣


ˤ

asiatic acid (Ȼ) madecassoside acid (ޥǥɻ),asiaticoside,madecassoside,

madasiatic acid, betulinic acid, thankunic acid, isothankunic acid ޤޤ롣12




triterpenes (ȥƥڥ) Ȥ

brahmic acid centellin, centellicinġġ..ʤɤޤޤƤ롣3-10


ĥλġ𤷤ƤǤǾؤ positive ʸ̤ϡˡȥƥڥ󥵥ݥɤȥإƥɤˤäƤ⤿餵ȹͤƤ롣



ڴԤǤѡ

ĥ

ݸ

Ͻѡ11-13

ѡ1415

̡16

ѡ1718

¡ݸ19

ڻѡ20

ۺѡ21

ѡ22

ݸѡ2324

Ǣºѡ25

륹26

ٶݡ27

ѡ28

ݡ29

ѡ30-32

𤵤Ƥ뤬ϿݸѤˤĤƼ夲롣



in Vitro θ in vivo ˤ븦

ˤ׾ˤơĥλĿݸѤ͡¦̤鸦椵졢𤵤Ƥ롣



ĥʪ

150 g/ml ǻ٤ǥ륳󥨥ƥ顼AchEˤ 50 ˳뤳Ȥ狼äƤ롣33


ޤAwad ϡC.asiatica ʪˤϥ륿ߥæúǹǡGADˤγ

40 ʾι̤뤳ȤŦƤ롣34



륿ߥæúǹǡGADˤϹưʪзϤ¿ȯãʪǤ áݥߥGABAˤǤǤ롣


ĤޤGAD γˤзϤˤơGABA ǻ٤徺԰ºѤԤ롣




ФΤΤФ̤ȤƤϡC.asiatica ʪ100/ml ǻ٤ǡʹ֤ SH-SY5Y ˦ˤƼ͵οĹ뤳ȤǧƤ롣35



˾ܺ٤ʸˤä

C.asiatica ˴ޤޤƤ asiatic acid (Ȼ) ͶƳʪˤꡢ˹⤤ݸѤͭ뤳ȤǧäƤ롣


ϥ륿ߥͶƳ NO λȥ륿󡢥륿ڥ륪ȤäƼطǤǻ٤򲼤뤳Ȥˤäơ36



ºݤ˥åȤȤ

200mg/kg (νŤ) ǻ٤Ϳ¸ǡ C.asiatica οʪݼ褹뤳Ȥǥޥ󥸥ǥҥɡMDAˤ̤򸺤餷륿ȥ顼CAT˥٥äѻ줿


ˤC.asiatica ϡιѤˤ국ϤɤƶͿǽ뤳ȤɮԤϻŦƤ롣37



C.asiatica

100,300 mg/kg ̤ǡͭդʹѤͭˤ국ϤβԤǤ𤷤Ƥ롣38

ĤޤꡢθȤʤꤦȥ쥹λɸȤʤꤦ롢 MDA 䥰륿٥¬ȡʪͿˤϤ٤Ƥͤͭդʲǧ줿ΤǤ롣



Rao

C.asiatica ʪ15֥ޥ˷и200,500,700,1000mg/kg Ϳ뤷ؽǽϵڤӵϤˤĤƤѲĴƤ롣


̤

åȳϤ CA3˦ˤACEγȼ͵οĹǧ줿ΤǤ롣39



̤θˤƤ⡢2,4,6ml/kg ̤2,4,6֡C.asiaticaդʪͤΥåȤͿȡ6ml/kg,6֤ͿǼ͵οĹߤȤ줿40



ˡϤǤΥߥɦ¥ץ顼̤򸺤餹Ȥ¸ߤƤ롣41


Shinomol Muralidhara ϡC.asiatica λĻȥ쥹ؤӥߥȥɥꥢǽͽɤ뤳Ȥ𤷤Ƥ롣

ĤޤꡢMDA 饸Ǽʤɤ˸̤ڤܤȥ쥹򸺤餹ȤǥߥȥɥꥢεǽݤĤΤǤ롣42



5001000 mg/kg ̤̰¸˹ѤǧƤ롣43


C.asiatica åȤ 300mg/kg,60ַиͿ 뾲򡢾ǾϤѲĴ٤椬¸ߤ롣48




ץƥ󥫥ܥ˥PCOˤβͭդ˸뤳ȤˤäơݸѤǧ줿


ޤ̤ʸǤϡ 100,200mg/kg ᥹ΥåȤͿ SOD CAT ͭդäǧ줿45




׾

ܻڤΤҤɤФơ36 C.asiatica Ϳ׳ؾͭդʲǧƤ롣46



Ǥǯۤ24͡4͡ʿǯ65.053.56Сˤоݤˡܻη C.asiatica οʪݼ褷Ƥ餤̤򸡾ڤƤ롣47


250,500,750mg 2ݼ褷Ƥ餤͡ɾˡǧεǽɾȡ̡750mgͿˤǧεǽζǧ줿


Ʊͤ Dev ϡǯ͡19͡22͡ˤˤƤΡC.asiatica ʪλǧεǽؤɤƶŦƤ롣


Ūˤ2Ϥ11ݼǡ WJCAT (Woodcock-Johnson Cognitive Abilities Test ) ȤǧεǽΤ٤ƥȤԤä


̡ɤƶͭշǧ줿ΤǤ롣48


ʿǯ65ФϷǯ60ͤоݤˡ C.asiatica ʪ 500mg 126ݼ褷Ƥ餦ȡMMSE (Mini Mental State Examination) ˤͭդʲǧ줿Ȥ⤢롣49




ա

C.asiatica Ͽ侩̤ݼ褹ȤۤȤɤξǤ㤫ݼ褹뤳ȤˤȻפҾɤ𤬤ޤ50-52


C.asiatica ϴ¡Ǥ˱ƶڤܤޤ­


Ūˤ CYP1A2,2C9,2D6 Ф˳ѤͭƤ뤿ᡢȤƤ C.asiatica ȤȤѤФ䤹ʤǽޤ


Newall ϥ᥹ΥåȤ C.asiatica иͿǥ𤷤Ƥޤ53


ޤǥνݼ褹ȼήȤ⤢ޤ54


;徺Ѥȡ;徺ѤΤǡǢ¤ɤ򤪻 C.asiatica ݼκݤˤݼ̤ĴɬפǤ53


ºݤ C.asiatica ݼĴΰȤơBriefly 6ݼ褷ΤʤȤ2֤ε򴫤Ƥޤ

ޤǥ椪Ӽνݼ򹵤ۤ褤褦Ǥ



ĥ۹Υ֥쥤աɤϡTORCH ɤȻפޤ
https://www.amazon.co.jp/dp/B012TF7YFW


iStock_000063321491_֥



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