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Rerationship between Concentrations of Lutein and StARD3 among Pediatric and Geriatric Himan Brain tissue

PMID: 27205891

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Abstract
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Introduction
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Efficacy of an Extract of Ocimum tenuiflorum(OciBest) in the Management of General stress:A Double-blind,Placebo-Controlled study.

PMID: 21977056

https://www.ncbi.nlm.nih.gov/pubmed/?term=21977056


Abstract
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References
(1)¡¡Defeudis FV (2002a) Bilobalide and Neuroprotection. Pharmacol

Res 46:565¡Ý568

(2)¡¡Zimmermann M, Colciaghi F, Cattabeni F, Di Luca M (2002)Ginkgo biloba extract: from molecular mechanisms to the
treatment of Alzheimer's disease. Cell Mol Biol 48:613¡Ý623

(3)¡¡Gohil K, Packer L (2002) Global gene expression analysis identifiescell and tissue specific actions of Ginkgo biloba extract, EGb761. Cell Mol Biol 48:625¡Ý631

(4)¡¡Oken B, Storzbach D, Kaye J (1998) The efficacy of Ginkgo bilobaon cognitive function in Alzheimer disease. Arch Neurol55:1409¡Ý1415

(5)¡¡Ni Y, Zhao B, Hou J, Xin W (1996) Preventive effect of Ginkgobiloba extract on apoptosis in rat cerebellar neuronal cellsinduced by hydroxyl radicals. Neurosci Lett 214:115¡Ý118

(6)¡¡DeFeudis F, Drieu K (2000) Ginkgo biloba extract (EGb 761) andCNS functions: basic studies and clinical applications. CurrDrug Targets 1:25¡Ý58

(7)¡¡Lien E, Ren S, Bui H, Wang R (1999) Quantitative structure-activityrelationship analysis of phenolic antioxidants. Free Radic BiolMed 26:285¡Ý294

(8)¡¡Smith J, Luo Y (2003) Elevation of oxidative free radicals inAlzheimer's disease models can be attenuated by Ginkgo bilobaextract EGb 761. J Alzheimer's Dis 5:287¡Ý300

(9)¡¡Pardon M, Joubert C, Perez-Diaz F, Christen Y, Launay J, Cohen-Salmon C (2000) In vivo regulation of cerebral monoamineoxidase activity in senescent controls and chronically stressedmice by long-term treatment with Ginkgo biloba extract (EGb761) Mech Ageing Dev 113:157¡Ý68

(10)¡¡Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, QuirionR (2000) The Ginkgo biloba extract (EGb 761) protectshippocampal neurons against cell death induced by betaamyloid.Eur J Neurosci 12:1882¡Ý1890

(11)¡¡Luo Y, Smith J, Paramasivam V, Burdick A, Curry K, Buford J,Khan I, Netzer W, Xu H, Butko P (2002) Inhibition of amyloidbetaaggregation and caspase-3 activation by the Ginkgo bilobaextract EGb761. Proc Natl Acad Sci USA 99:12197¡Ý12202

DeFeudis FV (1998) Ginkgo biloba extract (EGb 761): fromchemistry to clinic. Ullstein, Weisbaden, Germany

(12)¡¡Smith J, Burdick A, Golik P, Khan I, Wallace D, Luo Y (2002) Antiapoptoticproperties of Ginkgo biloba extract EGb 761 indifferentiated PC12 cells. Cell Mol Biol 48:699¡Á707

(13)¡¡Cohen-Salmon C, Venault P, Martin B, Raffalli-Sebille M, BarkatsM, Clostre F, Pardon M, Christen Y, Chapouthier G (1997)Effects of Ginkgo biloba extract (EGb 761) on learning andpossible actions on aging. J Physiol 91:291¡Ý300

(14)¡¡Smith P, Maclennan K, Darlington C (1996) The neuroprotectiveproperties of the Ginkgo biloba leaf: a review of the possiblerelationship to platelet-activating factor (PAF) J Ethnopharmacol50:131¡Ý139

(15)¡¡DeFeudis FV (2002b) Effects of Ginkgo biloba extract (EGb 761)on gene expression: possible relevance to neurologicaldisorders and age-associated cognitive impairment. Drug DevRes 57:214¡Ý235

(16)¡¡Oberpichler H, Sauer D, Rossberg C, Mennel HD, Krieglstein J(1990) PAF antagonist ginkgolide B reduces postischemicneuronal damage in rat brain hippocampus. J Cereb Blood FlowMetab 10:133¡Ý135

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